IRS1

Gene Symbol IRS1
Entrez Gene 3667
Alt Symbol HIRS-1
Species Human
Gene Type protein-coding
Description insulin receptor substrate 1
Other Description IRS-1
Swissprots P35568
Accessions AAB21608 AGG19175 AGG19176 AGG19177 AHG12642 AHG12643 AHG12644 CAD79961 CBL64020 EAW70838 EAW70839 P35568 AW469017 BC053895 AAH53895 EU831611 ACE87211 EU831698 ACE86532 S62539 AAB27175 NM_005544 NP_005535
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250}.
Top Pathways AMPK signaling pathway, cGMP-PKG signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer, PI3K-Akt signaling pathway

Phospho-IRS-1 (Ser318) (D51C3) Rabbit mAb - 5610 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D51C3
Western blot analysis of extracts from serum-starved C2C12 cells, untreated or insulin-treated (150 nM for 5 min.), using Phospho-IRS-1 (Ser318) (D51C3) Rabbit mAb (upper), or IRS-1 Antibody #3407 (lower).

Phospho-IRS-1 (Tyr1222) Antibody - 3066 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from CHO cells stably transfected with IRS-1, untreated or stimulated with insulin, using Phospho-IRS-1 (Tyr1222) Antibody (upper) or IRS-1 Antibody #2382 (lower).

Phospho-IRS-1 (Ser307) Antibody - 2381 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of MCF-7 cell extracts, unstimulated and insulin-stimulated (100 nM for 5 min), using IRS-1 Antibody #2382 (left) and Phospho-IRS-1 (Ser307) Antibody (right).

Phospho-IRS-1 (Ser789) Antibody - 2389 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells overexpressing IRS-1, untreated or treated with insulin for 15 minutes, using Phospho-IRS-1 (Ser789) Antibody (upper) or IRS-1 Antibody #2382 (lower). The CIP treatment abolished the immunoreactivity of Phospho-IRS-1 (Ser789) Antibody with IRS-1 (upper, right).

Phospho-IRS-1 (Tyr895) Antibody - 3070 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from CHO cells stably transfected with IRS-1, untreated or stimulated with insulin, using Phospho-IRS-1 (Tyr895) Antibody (upper) or IRS-1 Antibody #2382 (lower).

Phospho-IRS-1 (Ser612) Antibody - 2386 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of IRS-1 antibody-immunoprecipitated pellets from insulin (100 nM for 2 minutes) stimulated or nonstimulated CHO IR/IRS-1 cells, using Phospho-IRS-1 (Ser612) Antibody (upper) and control IRS-1 Antibody #2382 (lower).

Phospho-IRS-1 (Ser302) (34C7) Rabbit mAb - 2491 from Cell Signaling Technology

Prices $307.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 34C7
Western blot analysis of insulin treated (100 nM, 5 min) MCF7 and C2C12 cells using Phospho-IRS-1 (Ser302) (34C7) Rabbit mAb.

Phospho-IRS-1 (Ser612) (C15H5) Rabbit mAb - 3203 from Cell Signaling Technology

Prices $109.00, $297.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C15H5
Western blot analysis of cell extracts from CHO IR/IRS-1 cells, untreated or treated with insulin, using Phospho-IRS-1 (Ser612) (C15H5) Rabbit mAb (upper and middle) or IRS-1 Antibody #2382 (lower). The middle blot was treated with calf intestinal phosphatase (CIP) before antibody probing.

Phospho-IRS-1 (Ser332/336) Antibody - 2580 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell extracts from CHO cells overexpressing insulin receptor and IRS-1, untreated or treated with insulin, using Phospho-IRS-1 (Ser332/336) Antibody (upper and middle) or IRS-1 Antibody #2382 (lower). The middle blot was treated with calf intestinal phosphatase (CIP) before antibody probing.

Phospho-IRS-1 (Ser636/639) Antibody - 2388 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C2C12 cells, untreated or insulin-treated (100 nM, 5 min) using, Phospho-IRS-1 (Ser636/639) Antibody.

Phospho-IRS-1 (Ser1101) Antibody - 2385 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of IRS-1 (#2382) antibody-immunoprecipitated pellets from differentiated C2C12 cells, unstimulated, insulin-stimulated (100 nM for 15 min) or PMA-stimulated (200 mM for 30 min), using Phospho-IRS-1 (Ser1101) Antibody (upper) or IRS-1 Antibody #2382 (lower).

Phospho-IRS-1 (Ser302) Antibody - 2384 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from CHO IR/IRS-1 cells ( transfected with insulin receptor and IRS-1), untreated or insulin-treated (100 nM for 5 min), showing an increase in phospho-IRS-1 (Ser302) with insulin stimulation, using Phospho-IRS1 (Ser302) Antibody. To confirm phospho-specificity of the antibody, a duplicate membrane was treated with calf intestinal alkaline phosphatase (CIP) after Western transfer.

Phospho-IRS-1 (Ser612) (L7B8) Mouse mAb - 3193 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L7B8
Western blot analysis of extracts from differentiated C2C12 and CHO-IR/IRS-1 (CHO transfected with IR and IRS-1 cDNA) untreated or treated with insulin and λ phosphatase, using Phospho-IRS-1 (Ser612) (L7B8) Mouse mAb (upper), or IRS-1 Antibody #2382 (lower).

IRS-1 (D23G12) Rabbit mAb - 3407 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D23G12
Western blot analysis of MCF7, C2C12 and RD cell lines using IRS-1 (D23G12) Rabbit mAb.

IRS-1 Antibody - 2382 from Cell Signaling Technology

Prices $246.00, $596.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using IRS-1 Antibody.

IRS-1 (59G8) Rabbit mAb - 2390 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 59G8
Western blot analysis of extracts from various cell lines using IRS-1 (59G8) Rabbit mAb.

IRS-1 (L3D12) Mouse mAb - 3194 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L3D12
Western blot analysis of cell lysates from L6 and CHO cells overexpressing IRS-1 and insulin receptors, using IRS-1 (L3D12) Mouse mAb.

IRS-1 (C-20) - sc-559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRS-1 (C-20): sc-559. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tissue showing cytoplasmic staining of glandular cells.

p-IRS-1 (Tyr 941)-R - sc-17199-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
p-IRS-1 (Tyr 941): sc-17199. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

IRS-1 (A-19) - sc-560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRS-1 (A-19): sc-560. Western blot analysis of IRS-1 expression in A549 (A), Ramos (B) and BJAB (C) whole cell lysates.

IRS-1 (E-12) - sc-8038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRS-1 (E-12): sc-8038. Western blot analysis of IRS-1 expression in Ramos whole cell lysate.

IRS-1 (H-165) - sc-7200 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRS-1 (H-165): sc-7200. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic and nuclear staining of neuronal cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

p-IRS-1 (Ser 636) - sc-33957 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of IRS-1 phosphorylation in non-transfected: sc-117752 (A,D), untreated human IRS-1 transfected: sc-116569 (B,E) and lambda protein phosphatase (sc-200312A) treated human IRS-1 transfected: sc-116569 (C,F) 293T whole cell lysates. Antibodies tested include p-IRS-1 (Ser 636): sc-33957 (A,B,C) and IRS-1 (A-19): sc-560 (D,E,F).

p-IRS-1 (Ser 307) - sc-33956 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

p-IRS-1 (Ser 641) - sc-17197 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-IRS-1 (Ser 641): sc-17197. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic staining of neuronal cells and glial cells.
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