| Gene Symbol |
RAD18
|
| Entrez Gene |
56852
|
| Alt Symbol |
RNF73
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAD18 E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase RAD18|RAD18 homolog|RAD18, S. cerevisiae, homolog|RING finger protein 73|hHR18|hRAD18|postreplication repair protein RAD18|postreplication repair protein hRAD18p
|
| Swissprots |
Q9NRT6 Q58F55 Q9NS91
|
| Accessions |
AAX44049 EAW63948 EAW63949 Q9NS91 AB035274 BAA99284 AF169796 AAF80856 AK023075 BAB14392 AK123966 AK222771 BAD96491 AY004333 AAF86618 BC001302 AAH01302 DQ891197 ABM82123 DQ894380 ABM85306 DW433240 NM_020165 NP_064550
|
| Function |
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|