Xrcc6

Gene Symbol Xrcc6
Entrez Gene 14375
Alt Symbol 70kDa, G22p1, Ku70
Species Mouse
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 6
Other Description 5'-dRP/AP lyase Ku70|5'-deoxyribose-5-phosphate lyase Ku70|ATP-dependent DNA helicase 2 subunit 1|ATP-dependent DNA helicase II 70 kDa subunit|CTC box-binding factor 75 kDa subunit|CTC75|CTCBF|DNA repair protein XRCC6|Ku p70|X-ray repair cross-complementing protein 6|ku autoantigen protein p70 homolog|thyroid autoantigen 70 kDa
Swissprots P23475 Q8QZX7 Q62453 Q6GTV8 Q3UJL8 Q62382 Q62027 O88212
Accessions AAC52675 AAC53575 EDL04536 EDL04537 P23475 AB010282 BAA28874 AF483500 AAL90774 AF483501 AAL90775 AK088530 AK143570 BAE25441 AK146392 BAE27135 AK146394 BAE27137 AK146396 BAE27139 AK178816 BC031422 AAH31422 BC051085 BY292222 M38700 AAA39396 Z14157 CAA78526 XM_006520440 XP_006520503 XM_006520442 XP_006520505 XM_006520443 XP_006520506 XM_006520444 XP_006520507 XM_006520445 XP_006520508 XM_011245456 XP_011243758 XR_383982 NM_010247 NP_034377
Function Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-d
Subcellular Location Nucleus. Chromosome.
Top Pathways Non-homologous end-joining

Ku70 antibody (Ser5) - 70R-31324 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

XRCC6 antibody - 70R-30842 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Ku70 antibody - 70R-31325 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

XRCC6 Antibody - abx103789 from Abbexa

Host Rabbit
Clonality Polyclonal

X-Ray Repair Cross Complementing 6 (XRCC6), Polyclonal Antibody - MBS2017827 from MyBioSource

Prices $130.00, $150.00, $225.00, $290.00, $460.00, $1,095.00
Sizes 10 µg, 20 µg, 50 µg, 100 µg, 200 µg, 1 mg
Host Rabbit
Clonality Polyclonal

PSE1/Ku Protein Antibody - GWB-C3F758 from Genway Biotech

Prices $615.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone N9C1

Polyclonal Antibody to X-Ray Repair Cross Complementing 6 (XRCC6) - PAA316Mu01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to X-Ray Repair Cross Complementing 6 (XRCC6) - PAA316Mu02 from Cloud-clone

Host Rabbit
Clonality Polyclonal

anti-Ku70 / Ku80 antibody [162] - ARG62528 from Arigo Biolaboratories

anti-Ku70 antibody [N3H10] - ARG62529 from Arigo Biolaboratories

PSE1/Ku Protein Antibody (OAMA01316) - OAMA01316 from Aviva Systems Biology

Prices $585.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone N9C1

Ku-70, Polyclonal Antibody - MBS2537259 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2539381 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2535575 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2535838 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2539187 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2534580 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2539460 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2537415 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2538741 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Ku-70, Polyclonal Antibody - MBS2536698 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal
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