Xrcc6

Gene Symbol	Xrcc6
Entrez Gene	14375
Alt Symbol	70kDa, G22p1, Ku70
Species	Mouse
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 6
Other Description	5'-dRP/AP lyase Ku70|5'-deoxyribose-5-phosphate lyase Ku70|ATP-dependent DNA helicase 2 subunit 1|ATP-dependent DNA helicase II 70 kDa subunit|CTC box-binding factor 75 kDa subunit|CTC75|CTCBF|DNA repair protein XRCC6|Ku p70|X-ray repair cross-complementing protein 6|ku autoantigen protein p70 homolog|thyroid autoantigen 70 kDa
Swissprots	P23475 Q8QZX7 Q62453 Q6GTV8 Q3UJL8 Q62382 Q62027 O88212
Accessions	AAC52675 AAC53575 EDL04536 EDL04537 P23475 AB010282 BAA28874 AF483500 AAL90774 AF483501 AAL90775 AK088530 AK143570 BAE25441 AK146392 BAE27135 AK146394 BAE27137 AK146396 BAE27139 AK178816 BC031422 AAH31422 BC051085 BY292222 M38700 AAA39396 Z14157 CAA78526 XM_006520440 XP_006520503 XM_006520442 XP_006520505 XM_006520443 XP_006520506 XM_006520444 XP_006520507 XM_006520445 XP_006520508 XM_011245456 XP_011243758 XR_383982 NM_010247 NP_034377
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-d
Subcellular Location	Nucleus. Chromosome.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse XRCC6 Protein - abx069714 from Abbexa Category Protein Source E.coli Species Mouse

Recombinant X-Ray Repair Cross Complementing 6 (XRCC6) - RPA316Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant X-Ray Repair Cross Complementing 6 (XRCC6) - RPA316Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse X-ray repair cross-complementing protein 6(Xrcc6) - CSB-YP326067MO CSB-EP326067MO CSB-BP326067MO CSB-MP326067MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

X-Ray Repair Cross Complementing 6 (XRCC6), Recombinant Protein - MBS2018731 from MyBioSource Category Protein Prices $265.00, $480.00, $700.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

X-ray repair cross-complementing protein 6(Xrcc6) , Recombinant Protein - MBS1264976 from MyBioSource Category Protein Prices $2,360.00, $2,360.00, $2,785.00, $2,785.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Recombinant Mouse XRCC6 Protein - XRCC6-18640M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

XRCC6 Recombinant Protein (OPCD07990) - OPCD07990 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Recombinant Mouse Xrcc6 Protein, His-tagged - Xrcc6-448M from Creative Biomart Category Protein Source E. coli Species Mouse

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