| Gene Symbol |
ATP2A3
|
| Entrez Gene |
489
|
| Alt Symbol |
SERCA3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, Ca++ transporting, ubiquitous
|
| Other Description |
ATPase, Ca(2+)-transporting, ubiquitous|SR Ca(2+)-ATPase 3|adenosine triphosphatase, calcium|calcium pump 3|calcium-translocating P-type ATPase|sarco/endoplasmic reticulum Ca2+ -ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 3
|
| Swissprots |
O75501 O60901 Q16115 Q8TEX6 A8MZG0 D3DTJ8 Q93084 Q6JHX1 O60900 O75502 Q8TEX5
|
| Accessions |
CAA75739 CAA75747 CAA75748 CAA93736 CDM55639 CDM55640 CDM55641 CDM55642 CDM55643 CDM55644 EAW90460 EAW90461 EAW90462 EAW90463 EAW90464 EAW90465 EAW90466 EAW90467 EAW90468 EAW90469 EAW90470 Q93084 AA643105 AF068220 AAC24525 AF068221 AAC24526 AF458228 AAL78967 AF458229 AAL78968 AK292716 BAF85405 AY460339 AAR15415 BC035729 AAH35729 DQ893317 ABM84243 EU176809 ABW03610 S68239 AAB29700 Z69881 CAA93737 XM_005256656 XP_005256713 XM_011523881 XP_011522183 XM_011523882 XP_011522184 XM_011523883 XP_011522185 XM_011523884 XP_011522186 XM_011523885 XP_011522187 XM_011523886 XP_011522188 XM_011523887 XP_011522189 XM_011523888 XP_011522190 XM_011523889 XP_011522191 XM_011523890 XP_011522192 XM_011523891 XP_011522193 XM_011523892 XP_011522194 NM_005173 NP_005164 NM_174953 NP_777613 NM_174954 NP_777614 NM_174955 NP_777615 NM_174956 NP_777616 NM_174957 NP_777617 NM_174958 NP_777618
|
| Function |
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
|
| Subcellular Location |
Nucleus membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}.
|
| Tissue Specificity |
Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
|
| Top Pathways |
Alzheimer's disease, Calcium signaling pathway, Pancreatic secretion, cGMP-PKG signaling pathway
|