| Gene Symbol |
Tspan12
|
| Entrez Gene |
362326
|
| Alt Symbol |
Tm4sf12
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
tetraspanin 12
|
| Other Description |
tetraspanin-12|transmembrane 4 superfamily member 12|tspan-12
|
| Swissprots |
Q569A2
|
| Accessions |
Q569A2 BC092623 AAH92623 XM_008762784 XP_008761006 XM_008762785 XP_008761007 XM_008762786 XP_008761008 XM_008762787 XP_008761009 XM_008762788 XP_008761010 XM_008762789 XP_008761011 XM_008762790 XP_008761012 NM_001015026 NP_001015026
|
| Function |
Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1- MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|