Tspan12

Gene Symbol Tspan12
Entrez Gene 362326
Alt Symbol Tm4sf12
Species Rat
Gene Type protein-coding
Description tetraspanin 12
Other Description tetraspanin-12|transmembrane 4 superfamily member 12|tspan-12
Swissprots Q569A2
Accessions Q569A2 BC092623 AAH92623 XM_008762784 XP_008761006 XM_008762785 XP_008761007 XM_008762786 XP_008761008 XM_008762787 XP_008761009 XM_008762788 XP_008761010 XM_008762789 XP_008761011 XM_008762790 XP_008761012 NM_001015026 NP_001015026
Function Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1- MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

CompoZr® Knockout ZFN Kit - CKOZFN64709 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND64709 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TSPAN12 siRNA (Rat) - CRR6016 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

TSPAN12 - MBS8205301 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

shRNA set against Rat TSPAN12 (NM_001015026.1) - SHH436260 from Creative biogene

Category siRNA
Species Reactivities Rat

Rat TSPAN12 siRNA - orb300865 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

TSPAN12 shRNA Plasmid (Rat) - CHR6016 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Rat

TSPAN12 miRNA 3'UTR clone - MiUTR1R-08041 from Creative biogene

Species Reactivities Rat
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