| Gene Symbol | ACOT7 |
|---|---|
| Entrez Gene | 11332 |
| Alt Symbol | ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA thioesterase 7 |
| Other Description | CTE-IIa|acyl-CoA thioesterase 2|acyl-CoA thioesterase, long chain|brain acyl CoA hydrolase|brain acyl-CoA hydrolase|cytosolic acyl coenzyme A thioester hydrolase|long chain acyl-CoA thioester hydrolase |
| Swissprots | B3KQ12 A8K0K7 A8K232 Q9Y539 Q53Y78 Q5JYL5 O43703 Q9UJM9 A8K6B8 A8K837 Q5JYL4 Q5JYL6 Q5JYL2 Q9Y540 Q5JYL3 O00154 Q5TGR4 |
| Accessions | EAW71527 EAW71528 EAW71529 EAW71530 EAW71531 EAW71532 O00154 AB074415 BAC20174 AB074416 BAC20175 AB074417 BAC20176 AB074418 BAC20177 AB074419 BAC20178 AK057168 BAG51874 AK289572 BAF82261 AK290097 BAF82786 AK291583 BAF84272 AK292202 BAF84891 AK300831 BAG62482 AK304465 BAH14193 AL702662 BC017365 AAH17365 BG332214 BM807217 BQ067921 BT006888 AAP35534 BU594651 D88894 BAA24350 U91316 AAB61211 NM_007274 NP_009205 NM_181864 NP_863654 NM_181865 NP_863655 NM_181866 NP_863656 NM_181862 NM_181863 |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. |
| Subcellular Location | Isoform 1: Mitochondrion. |
| Tissue Specificity | Isoform 4 is expressed exclusively in brain. {ECO:0000269|PubMed:12435388}. |
| Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids |
ACOT7 CRISPR/Cas9 KO Plasmid (h) - sc-407483 from Santa Cruz Biotechnology
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ACOT7 HDR Plasmid (h) - sc-407483-HDR from Santa Cruz Biotechnology
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ACOT7 Double Nickase Plasmid (h) - sc-407483-NIC from Santa Cruz Biotechnology
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ACOT7 Double Nickase Plasmid (h2) - sc-407483-NIC-2 from Santa Cruz Biotechnology
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ACOT7 CRISPR Activation Plasmid (h) - sc-407483-ACT from Santa Cruz Biotechnology
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ACOT7 CRISPR Activation Plasmid (h2) - sc-407483-ACT-2 from Santa Cruz Biotechnology
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ACOT7 Lentiviral Activation Particles (h) - sc-407483-LAC from Santa Cruz Biotechnology
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ACOT7 Lentiviral Activation Particles (h2) - sc-407483-LAC-2 from Santa Cruz Biotechnology
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ACOT7 siRNA (h) - sc-88501 from Santa Cruz Biotechnology
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ACOT7 shRNA Plasmid (h) - sc-88501-SH from Santa Cruz Biotechnology
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ACOT7 shRNA (h) Lentiviral Particles - sc-88501-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU112971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2731 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12039 from Sigma-Aldrich
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ACOT7 siRNA (Human) - CRH7759 from Cohesion Biosciences
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ACOT7 - MBS8220575 from MyBioSource
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shRNA set against Human ACOT7 (NM_181866.2) - SHH230466 from Creative biogene
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shRNA set against Human ACOT7(NM_181864.2) - SHG030257 from Creative biogene
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shRNA set against Human ACOT7(NM_181865.2) - SHG030293 from Creative biogene
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shRNA set against Human ACOT7(NM_181866.2) - SHG030329 from Creative biogene
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shRNA set against Human ACOT7(NM_007274.3) - SHG030447 from Creative biogene
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ACOT7 shRNA Plasmid (Human) - CHH7759 from Cohesion Biosciences
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ACOT7 miRNA 3'UTR clone - MiUTR1H-00108 from Creative biogene
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ACOT7 miRNA 3'UTR clone - MiUTR1H-00109 from Creative biogene
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