CUBN

Gene Symbol	CUBN
Entrez Gene	8029
Alt Symbol	IFCR, MGA1, gp280
Species	Human
Gene Type	protein-coding
Description	cubilin (intrinsic factor-cobalamin receptor)
Other Description	460 kDa receptor|cubilin|cubilin precursor variant 1|cubilin precursor variant 2|intestinal intrinsic factor receptor|intrinsic factor-vitamin B12 receptor
Swissprots	Q5VTA6 O60494 B0YIZ4 Q96RU9
Accessions	AAK61829 AAK61830 ACA05973 ACA05974 EAW86221 O60494 AB209880 BAD93117 AF034611 AAC82612 AF086456 AK074536 BAG51968 AK075228 BAG52089 AK308290 AK309623 AK310404 BP270790 BP271329 XM_011519708 XP_011518010 XM_011519709 XP_011518011 XM_011519710 XP_011518012 XM_011519711 XP_011518013 NM_001081 NP_001072
Function	Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269|PubMed:10371504, ECO:0000269|PubMed:11606717, ECO:0000269|PubMed:11717447, ECO:0000269|PubMed:14576052, ECO:0000269|P
Subcellular Location	Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells. {ECO:0000250}.
Tissue Specificity	Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
Top Pathways	Vitamin digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human CUBN / Cubilin ELISA Kit (Sandwich ELISA) - LS-F8225 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.112 ng/ml Range 0.313-20 ng/ml

Dog CUBN / Cubilin ELISA Kit (Sandwich ELISA) - LS-F11246 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Rat CUBN / Cubilin ELISA Kit (Sandwich ELISA) - LS-F11245 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.313-20 ng/ml

Human Cubilin ELISA Kit - abx151206 from Abbexa Category ELISA Kit Sensitivity 0.34 ng/ml Range 0.781 ng/ml - 50 ng/ml

Cubilin (CUBN), Human, ELISA Kit - CSB-EL006213HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 2.35 pg/ml Range 9.38 pg/ml-600 pg/ml

Cubilin (CUBN), Human, ELISA Kit - SEC411Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.34ng/mL Range 0.78 -50ng/mL

Cubilin (CUBN), Human, ELISA Kit - E01C2178 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Cubilin, CUBN, Human, ELISA Kit - E9664h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t

Cubilin, ELISA Kit - MBS101696 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cubilin, ELISA Kit - MBS078158 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cubilin, ELISA Kit - MBS086118 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.625ng/ml-20ng/ml.

Cubilin, ELISA Kit - MBS101256 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cubilin, ELISA Kit - MBS062098 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cubilin, ELISA Kit - MBS077249 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cubilin, ELISA Kit - MBS078026 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cubilin (intrinsic factor-cobalamin receptor) , ELISA Kit - MBS904353 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.35 pg/ml. Range 9.38 pg/ml-600 pg/ml.

ELISA Kit for Cubilin (CUBN) - SEC411Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.34ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

ELISA Kit for Cubilin (CUBN) - SEC411Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.114ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Cubilin(CUBN) ELISA kit - CSB-EL006213HU from Cusabio Category ELISA Kit Sensitivity 2.35 pg/ml Range 9.38 pg/ml-600 pg/ml

ELISA Kit for Cubilin (CUBN) - SEC411Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.34ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA's were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human CUBN / Cubilin ELISA Kit (Custom ELISA) - LS-F20516 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse CUBN / Cubilin ELISA Kit (Custom ELISA) - LS-F20517 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human Cubilin (CUBN) ELISA Kit - EKU03524 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.112 ng/mL Range 0.312-20 ng/mL

Cubilin (CUBN), Human, ELISA Kit - DL-CUBN-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.78 -50 ng/mL

Human CUBN (Cubilin) ELISA Kit - E-EL-H2463 from Elabscience Category ELISA Kit Sensitivity 0.47 ng/mL Range 0.78—50 ng/mL

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