CUBN

Gene Symbol	CUBN
Entrez Gene	8029
Alt Symbol	IFCR, MGA1, gp280
Species	Human
Gene Type	protein-coding
Description	cubilin (intrinsic factor-cobalamin receptor)
Other Description	460 kDa receptor|cubilin|cubilin precursor variant 1|cubilin precursor variant 2|intestinal intrinsic factor receptor|intrinsic factor-vitamin B12 receptor
Swissprots	Q5VTA6 O60494 B0YIZ4 Q96RU9
Accessions	AAK61829 AAK61830 ACA05973 ACA05974 EAW86221 O60494 AB209880 BAD93117 AF034611 AAC82612 AF086456 AK074536 BAG51968 AK075228 BAG52089 AK308290 AK309623 AK310404 BP270790 BP271329 XM_011519708 XP_011518010 XM_011519709 XP_011518011 XM_011519710 XP_011518012 XM_011519711 XP_011518013 NM_001081 NP_001072
Function	Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269|PubMed:10371504, ECO:0000269|PubMed:11606717, ECO:0000269|PubMed:11717447, ECO:0000269|PubMed:14576052, ECO:0000269|P
Subcellular Location	Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells. {ECO:0000250}.
Tissue Specificity	Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
Top Pathways	Vitamin digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human Cubilin peptide - ab68599 from Abcam Category Peptide

Human Cubilin Protein - abx066183 from Abbexa Category Protein Source E.coli Species Human

Human Cubilin Protein - abx066186 from Abbexa Category Protein Source E.coli Species Human

Cubilin (CUBN), Human - 20-8464 from ARP American Research Products Category Protein Prices $529.00 Sizes 50 µg Source E.coli Species Human

Cubilin (CUBN), Human - 20-8465 from ARP American Research Products Category Protein Prices $529.00 Sizes 50 µg Source E.coli Species Human

Recombinant Cubilin (CUBN) - RPC411Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cubilin (CUBN) - RPC411Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cubilin (CUBN) - RPC411Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cubilin (CUBN) - RPC411Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cubilin (CUBN) - RPC411Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Cubilin (CUBN) - RPC411Ra02 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Cubilin (CUBN) - RPC411Ra03 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Cubilin (CUBN) - RPC411Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Cubilin (CUBN) - RPC411Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Cubilin(CUBN) ,partial - CSB-YP006213HU CSB-EP006213HU CSB-BP006213HU CSB-MP006213HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CUBN Blocking Peptide - CBP4380 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Cubilin (CUBN) - RPU141055 from Biomatik Category Protein Prices $253.00, $506.00, $759.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

Cubilin (CUBN) - RPU141058 from Biomatik Category Protein Prices $253.00, $506.00, $759.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

CUBN Blocking Peptide - abx161591 from Abbexa Category Peptide Species Human

CUBN Peptide, Human - M34GP03835H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cubilin peptide - orb12917 from Biorbyt Category Peptide Prices $170.00 Sizes 1 mg

Recombinant Cubilin (CUBN) - RPU41055 from Biomatik Category Protein Prices $202.00, $396.00, $633.00, $754.40 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

Recombinant Cubilin (CUBN) - RPU41058 from Biomatik Category Protein Prices $202.00, $396.00, $633.00, $754.40 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

CUBN Recombinant Protein (OPCD02553) - OPCD02553 from Aviva Systems Biology Category Protein Source E.coli Species Human

CUBN Recombinant Protein (OPCD02558) - OPCD02558 from Aviva Systems Biology Category Protein Source E.coli Species Human

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