| Gene Symbol |
Alox12e
|
| Entrez Gene |
11685
|
| Alt Symbol |
8-LOX, AW259591, Alox12-ps1, Alox12-ps2, Aloxe, e-LOX1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
arachidonate lipoxygenase, epidermal
|
| Other Description |
12-LOX|arachidonate 12-lipoxygenase, epidermal|arachidonate 12-lipoxygenase, epidermal-type
|
| Swissprots |
Q91YW6 P55249
|
| Accessions |
AAC52324 EDL12553 P55249 AK138743 BAE23765 BC013751 AAH13751 BC051047 AAH51047 U39200 AAC52869 X99252 CAA67625 XM_006532034 XP_006532097 XM_006532035 XP_006532098 XM_006537112 XP_006537175 XM_006537113 XP_006537176 NM_145684 NP_663717
|
| Function |
Non-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE. {ECO:0000269|PubMed:8798535, ECO:0000269|PubMed:9037187}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.
|
| Tissue Specificity |
Expressed in epidermis. {ECO:0000269|PubMed:8798535}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism
|