Gene Symbol | Alox12e |
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Entrez Gene | 11685 |
Alt Symbol | 8-LOX, AW259591, Alox12-ps1, Alox12-ps2, Aloxe, e-LOX1 |
Species | Mouse |
Gene Type | protein-coding |
Description | arachidonate lipoxygenase, epidermal |
Other Description | 12-LOX|arachidonate 12-lipoxygenase, epidermal|arachidonate 12-lipoxygenase, epidermal-type |
Swissprots | Q91YW6 P55249 |
Accessions | AAC52324 EDL12553 P55249 AK138743 BAE23765 BC013751 AAH13751 BC051047 AAH51047 U39200 AAC52869 X99252 CAA67625 XM_006532034 XP_006532097 XM_006532035 XP_006532098 XM_006537112 XP_006537175 XM_006537113 XP_006537176 NM_145684 NP_663717 |
Function | Non-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE. {ECO:0000269|PubMed:8798535, ECO:0000269|PubMed:9037187}. |
Subcellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}. |
Tissue Specificity | Expressed in epidermis. {ECO:0000269|PubMed:8798535}. |
Top Pathways | Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism |
Alox12e CRISPR/Cas9 KO Plasmid (m) - sc-419087 from Santa Cruz Biotechnology
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Alox12e HDR Plasmid (m) - sc-419087-HDR from Santa Cruz Biotechnology
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Alox12e Double Nickase Plasmid (m) - sc-419087-NIC from Santa Cruz Biotechnology
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Alox12e Double Nickase Plasmid (m2) - sc-419087-NIC-2 from Santa Cruz Biotechnology
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Alox12e CRISPR Activation Plasmid (m) - sc-419087-ACT from Santa Cruz Biotechnology
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Alox12e CRISPR Activation Plasmid (m2) - sc-419087-ACT-2 from Santa Cruz Biotechnology
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Alox12e Lentiviral Activation Particles (m) - sc-419087-LAC from Santa Cruz Biotechnology
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Alox12e Lentiviral Activation Particles (m2) - sc-419087-LAC-2 from Santa Cruz Biotechnology
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Alox12e siRNA (m) - sc-141027 from Santa Cruz Biotechnology
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Alox12e shRNA Plasmid (m) - sc-141027-SH from Santa Cruz Biotechnology
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Alox12e shRNA (m) Lentiviral Particles - sc-141027-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU052881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26590 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26590 from Sigma-Aldrich
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ALOX12E siRNA (Mouse) - CRM0145 from Cohesion Biosciences
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ALOX12E - MBS8219741 from MyBioSource
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shRNA set against Mouse Alox12e (NM_145684.1) - SHH235358 from Creative biogene
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Alox12e CRISPR/Cas9 KO Plasmid (m2) - sc-419087-KO-2 from Santa Cruz Biotechnology
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Alox12e HDR Plasmid (m2) - sc-419087-HDR-2 from Santa Cruz Biotechnology
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ALOX12E shRNA Plasmid (Mouse) - CHM0145 from Cohesion Biosciences
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ALOX12E miRNA 3'UTR clone - MiUTR1M-01419 from Creative biogene
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