Gene Symbol | Cdkn2a |
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Entrez Gene | 25163 |
Alt Symbol | Arf, INK4A, MTS1, p16, p16Cdkn2a, p19ARF |
Species | Rat |
Gene Type | protein-coding |
Description | cyclin-dependent kinase inhibitor 2A |
Other Description | CDK4I|Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4)|cdkn2a {ECO:0000312|EMBL:AAL76336.1, ECO:0000312|RGD:2323}|cdkn2a {ECO:0000312|EMBL:AAL76338.1, ECO:0000312|RGD:2323}|cell cycle inhibitor|cell cycle regulator|cyclin-dependent kinase 4 inhibitor A|cyclin-dependent kinase inhibitor 2a p16Ink4a|cyclin-dependent kinase inhibitor 2a p19Arf|p16-INK4|p16-INK4a |
Swissprots | Q9R0Z3 |
Accessions | ABC69989 ABC69990 ABC69991 BAC16249 EDL97744 Q8QZZ9 Q9R0Z3 AF474974 AAL76336 AF474975 AAL76337 AF474976 AAL76338 AF474977 AAL76339 AY679727 AAT92509 AY679728 AAT92510 L81167 AAD48924 NM_031550 NP_113738 |
Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity). {ECO:0000250|UniProtKB:P51480}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Expressed in spleen, liver and lung. Not detected in kidney, colon, stomach or brain. {ECO:0000269|PubMed:9032263}. |
Top Pathways | Cell cycle, Glioma, Pancreatic cancer, Non-small cell lung cancer, Bladder cancer |
Cyclin-dependent kinase inhibitor 2A, isoform 2, Cdkn2a, Rat, ELISA Kit - E0794r from ARP American Research Products
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Interferonγ-Inducible Protein 16, IFI16/P16, Rat, ELISA Kit - YHB0601Ra from ARP American Research Products
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P16, Rat, ELISA Kit - YHB0819Ra from ARP American Research Products
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S100 Calcium Binding Protein A4 (S100A4), Rat, ELISA Kit - SEC020Ra from ARP American Research Products
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Rat CDKN2A ELISA Kit - RC0534 from NeoScientific
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Rat p16 ELISA Kit - RA0008 from NeoScientific
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cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) , ELISA Kit - MBS9326035 from MyBioSource
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interferongamma-inducible protein 16, IFI16/P16, ELISA Kit - MBS9300834 from MyBioSource
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Rat CDKN2A(Cyclin Dependent Kinase Inhibitor 2A) ELISA Kit - E-EL-R0293 from Elabscience
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Rat IFI16/p16(Interferon-Inducible Protein 16) ELISA Kit - E-EL-R0547 from Elabscience
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Rat IFI16/p16 (Interferon-Inducible Protein 16) CLIA Kit - E-CL-R0383 from Elabscience
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IFI16/p16, ELISA Kit - MBS2505935 from MyBioSource
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Rat Antioncogene p16 protein ELISA - E02A0001 from BlueGene Biotech
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Rat Cyclin Dependent Kinase Inhibitor 2A ELISA - E02C0527 from BlueGene Biotech
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ELISA Kit for S100 Calcium Binding Protein A4 (S100A4) - SEC020Ra from Cloud-clone
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Rat CDKN2A(Cyclin Dependent Kinase Inhibitor 2A) ELISA Kit - E-EL-R0293 from Iwai North America Inc.
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Rat IFI16/p16 ELISA Kit - abx054131 from Abbexa
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IFI16/p16 (Interferon-Inducible Protein 16), CLIA Kit - MBS2532028 from MyBioSource
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IFI16/p16 - EKR2138 from Nordic BioSite
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Rat Cdkn2a ELISA Kit - E075644 from Biobool
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CDKN2A ELISA Kit (Rat) (OKEH04377) - OKEH04377 from Aviva Systems Biology
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Rat p16 ELISA Kit - ERA0008 from ABclonal
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Rat CDKN2A ELISA Kit - ERC0534 from ABclonal
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Rat Cyclin-dependent kinase inhibitor 2A, isoform 1 ELISA - EK5093 from Signalway Antibody
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Cyclin-dependent kinase inhibitor 2A, ELISA Kit - MBS9428919 from MyBioSource
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