| Gene Symbol |
Cdkn2a
|
| Entrez Gene |
25163
|
| Alt Symbol |
Arf, INK4A, MTS1, p16, p16Cdkn2a, p19ARF
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase inhibitor 2A
|
| Other Description |
CDK4I|Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4)|cdkn2a {ECO:0000312|EMBL:AAL76336.1, ECO:0000312|RGD:2323}|cdkn2a {ECO:0000312|EMBL:AAL76338.1, ECO:0000312|RGD:2323}|cell cycle inhibitor|cell cycle regulator|cyclin-dependent kinase 4 inhibitor A|cyclin-dependent kinase inhibitor 2a p16Ink4a|cyclin-dependent kinase inhibitor 2a p19Arf|p16-INK4|p16-INK4a
|
| Swissprots |
Q9R0Z3
|
| Accessions |
ABC69989 ABC69990 ABC69991 BAC16249 EDL97744 Q8QZZ9 Q9R0Z3 AF474974 AAL76336 AF474975 AAL76337 AF474976 AAL76338 AF474977 AAL76339 AY679727 AAT92509 AY679728 AAT92510 L81167 AAD48924 NM_031550 NP_113738
|
| Function |
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity). {ECO:0000250|UniProtKB:P51480}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in spleen, liver and lung. Not detected in kidney, colon, stomach or brain. {ECO:0000269|PubMed:9032263}.
|
| Top Pathways |
Cell cycle, Glioma, Pancreatic cancer, Non-small cell lung cancer, Bladder cancer
|