BNIP3

Gene Symbol BNIP3
Entrez Gene 664
Alt Symbol NIP3
Species Human
Gene Type protein-coding
Description BCL2/adenovirus E1B 19kDa interacting protein 3
Other Description BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Swissprots O14620 Q96GP0 Q12983
Accessions AAW62256 CAI45349 EAW49143 Q12983 AF002697 AAC16738 AK130264 AK222626 BAD96346 AK295136 BAG58159 BC009342 BC021989 AAH21989 BC067818 AAH67818 BC080643 AAH80643 BX647339 HQ448726 ADQ33204 HY049371 U15174 AAC00022 NM_004052 NP_004043
Function Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.
Subcellular Location Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
Top Pathways Legionellosis

BNIP3 293 Cell Lysate - 408521 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

BNIP3 Overexpression Lysate (Native) - NBL1-08014 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: BNIP3 Overexpression Lysate (Adult Normal) [NBL1-08014] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BNIP3.

BNIP3 Over-expression Lysate Product - GWB-1A565B from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

BNIP3 Overexpression Lysate (Denatured) - H00000664-T05 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human BNIP3 Knockdown Stable Cell Line - CSC-DC001488 from Creative biogene

Category Cell Line
Species Human
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