GLI3

Gene Symbol GLI3
Entrez Gene 2737
Alt Symbol ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV
Species Human
Gene Type protein-coding
Description GLI family zinc finger 3
Other Description GLI-Kruppel family member GLI3|glioma-associated oncogene family zinc finger 3|oncogene GLI3|transcriptional activator GLI3|zinc finger protein GLI3
Swissprots A4D1W1 Q75MU9 Q9UDT5 O75219 Q9UJ39 P10071 Q17RW4 Q75MT0
Accessions AAP21869 AAS01998 AAS02015 CAB59315 EAL24002 EAW94144 EAW94145 P10071 AA330409 AI863961 AK299299 BAG61313 AK308429 BC032660 BC113616 AAI13617 BC117168 AAI17169 BF194991 BI497308 DA713549 M57609 AAA52564 XM_005249703 XP_005249760 XM_005249704 XP_005249761 XM_011515272 XP_011513574 XM_011515273 XP_011513575 XM_011515274 XP_011513576 NM_000168 NP_000159
Function Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}.
Subcellular Location Nucleus. Cytoplasm. Cell projection, cilium. Note=GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Translocation to the nucleus is promoted by interaction with ZIC1.
Tissue Specificity Is expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway

Human Gli3 peptide - ab69917 from Abcam

Category Peptide

Human Gli3 protein fragment - ab152429 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab152429 stained with Coomassie Blue.

GLI3 Antibody Blocking Peptide - LS-E26050 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human GLI-3 Protein - H00002737-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

GLI3 Immunizing peptide - orb17576 from Biorbyt

Category Peptide
Prices $247.00
Sizes 100 μg
Species Human, Mouse, Rat

Human GLI3 Protein - abx066771 from Abbexa

Category Protein
Source E.coli
Species Human

GLI3 Peptide - AC21-0878-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

GLI3 - H00002737-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

GLI3 - H00002737-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

GLI Family Zinc Finger Protein 3 (GLI3), Human - 20-9396 from ARP American Research Products

Category Protein
Prices $489.00
Sizes 50 µg
Source E.coli
Species Human

GLI3 Peptide - 45-675P from ProSci

Category Peptide
Prices $175.00
Sizes 100 µg

Recombinant GLI Family Zinc Finger Protein 3 (GLI3) - RPJ716Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant GLI Family Zinc Finger Protein 3 (GLI3) - RPJ716Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant GLI Family Zinc Finger Protein 3 (GLI3) - RPJ716Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant DNA-directed RNA polymerase subunit alpha(rpoA) - CSB-YP359058SWW CSB-EP359058SWW CSB-BP359058SWW CSB-MP359058SWW from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Salmonella

Recombinant Human Transcriptional activator GLI3(GLI3) ,partial - CSB-YP009501HU CSB-EP009501HU CSB-BP009501HU CSB-MP009501HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

GLI3, Peptide - MBS426356 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human, Mouse, Rat, Dog

GLI-3 Recombinant Protein Antigen - NBP1-89275PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

GLI3 Peptide, Human - M34GP06316H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

GLI3 Recombinant Protein (OPCD03575) - OPCD03575 from Aviva Systems Biology

Category Protein
Source E.coli
Species Human

GLI Family Zinc Finger Protein 3 (GLI3), Recombinant Protein - MBS2011976 from MyBioSource

Category Protein
Prices $185.00, $380.00, $585.00
Sizes 10 µg, 50 µg, 100 µg
Source Prokaryotic expression
Species Human
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