| Gene Symbol |
Ace2
|
| Entrez Gene |
70008
|
| Alt Symbol |
2010305L05Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
|
| Other Description |
ACE-related carboxypeptidase|angiotensin I converting enzyme 2|angiotensin-converting enzyme 2
|
| Swissprots |
Q8R0I0 Q99N70 Q99N71
|
| Accessions |
EDL40761 Q8R0I0 AB053181 BAB40431 AB053182 BAB40432 AI115946 AK008530 BAB25723 AK135357 BAE22502 AK141604 BAE24759 BC026801 AAH26801 BY722909 EF408739 ABN80105 EF408740 ABN80106 GQ262785 ACT66269 NM_001130513 NP_001123985 NM_027286 NP_081562
|
| Function |
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury. {ECO:0000269|PubMed:12075344, ECO:0000269|PubMed:12967627, ECO:0000269|PubMed:16001071}.
|
| Subcellular Location |
Processed angiotensin-converting enzyme 2: Secreted {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, kidney and forebrain (at protein level). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on vascular endothelial and airway epithelial cells. {ECO:0000269|PubMed:12487024, ECO:0000269|PubMed:15949646, ECO:0000269|PubMed:16001071}.
|
| Top Pathways |
Protein digestion and absorption, Renin-angiotensin system
|