| Gene Symbol |
Plat
|
| Entrez Gene |
18791
|
| Alt Symbol |
AU020998, AW212668, D8Ertd2e, tPA
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
plasminogen activator, tissue
|
| Other Description |
t-plasminogen activator|tissue-type plasminogen activator
|
| Swissprots |
Q91VP2 Q6P7U0 P11214
|
| Accessions |
EDL32879 P11214 AK053476 AK135857 BAE22698 AK135965 BAE22749 AK141665 AK159620 AK166639 BC011256 AAH11256 BC057967 AAH57967 BC061508 AAH61508 CJ151826 DV644940 J03520 AAA40470 NM_008872 NP_032898
|
| Function |
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
|
| Subcellular Location |
Secreted, extracellular space.
|
| Top Pathways |
Complement and coagulation cascades, Transcriptional misregulation in cancer
|