Gene Symbol | Plat |
---|---|
Entrez Gene | 18791 |
Alt Symbol | AU020998, AW212668, D8Ertd2e, tPA |
Species | Mouse |
Gene Type | protein-coding |
Description | plasminogen activator, tissue |
Other Description | t-plasminogen activator|tissue-type plasminogen activator |
Swissprots | Q91VP2 Q6P7U0 P11214 |
Accessions | EDL32879 P11214 AK053476 AK135857 BAE22698 AK135965 BAE22749 AK141665 AK159620 AK166639 BC011256 AAH11256 BC057967 AAH57967 BC061508 AAH61508 CJ151826 DV644940 J03520 AAA40470 NM_008872 NP_032898 |
Function | Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. |
Subcellular Location | Secreted, extracellular space. |
Top Pathways | Complement and coagulation cascades, Transcriptional misregulation in cancer |
tPA CRISPR/Cas9 KO Plasmid (m) - sc-422290 from Santa Cruz Biotechnology
|
||||||||
tPA HDR Plasmid (m) - sc-422290-HDR from Santa Cruz Biotechnology
|
||||||||
tPA Double Nickase Plasmid (m) - sc-422290-NIC from Santa Cruz Biotechnology
|
||||||||
tPA Double Nickase Plasmid (m2) - sc-422290-NIC-2 from Santa Cruz Biotechnology
|
||||||||
tPA CRISPR Activation Plasmid (m) - sc-422290-ACT from Santa Cruz Biotechnology
|
||||||||
tPA CRISPR Activation Plasmid (m2) - sc-422290-ACT-2 from Santa Cruz Biotechnology
|
||||||||
tPA Lentiviral Activation Particles (m) - sc-422290-LAC from Santa Cruz Biotechnology
|
||||||||
tPA Lentiviral Activation Particles (m2) - sc-422290-LAC-2 from Santa Cruz Biotechnology
|
||||||||
tPA siRNA (m) - sc-36706 from Santa Cruz Biotechnology
|
||||||||
tPA shRNA Plasmid (m) - sc-36706-SH from Santa Cruz Biotechnology
|
||||||||
tPA shRNA (m) Lentiviral Particles - sc-36706-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU036431 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN38843 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38843 from Sigma-Aldrich
|
||||||||
PLAT siRNA (Mouse) - CRM3111 from Cohesion Biosciences
|
||||||||
shRNA set against Mouse PLAT (NM_008872.2) - SHH377040 from Creative biogene
|
||||||||
Mouse PLAT siRNA - orb282587 from Biorbyt
|
||||||||
PLAT shRNA Plasmid (Mouse) - CHM3111 from Cohesion Biosciences
|
||||||||