Gene Symbol |
Krt18
|
Entrez Gene |
16668
|
Alt Symbol |
CK18, K18, Krt1-18
|
Species |
Mouse
|
Gene Type |
protein-coding
|
Description |
keratin 18
|
Other Description |
CK-18|Endo B|cytokeratin endo B|cytokeratin-18|keratin D|keratin complex 1, acidic, gene 18|keratin, type I cytoskeletal 18|keratin-18
|
Swissprots |
Q3TIX1 Q3TJW7 Q61766 P05784 Q3TJH6
|
Accessions |
AAA37552 CAA68365 EDL04011 P05784 AK145413 BAE26424 AK167072 BAE39232 AK167265 BAE39378 AK167432 BAE39519 AK167469 BAE39553 AK167676 BAE39725 AW539037 BC020474 BC089022 AAH89022 CV561123 M11686 AAA39390 M36376 AAA39373 NM_010664 NP_034794
|
Function |
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:17213200}.
|
Subcellular Location |
Nucleus matrix {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}.
|
Tissue Specificity |
Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2416755, ECO:0000269|PubMed:2454868, ECO:0000269|PubMed:7504637}.
|