Gene Symbol | Krt18 |
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Entrez Gene | 16668 |
Alt Symbol | CK18, K18, Krt1-18 |
Species | Mouse |
Gene Type | protein-coding |
Description | keratin 18 |
Other Description | CK-18|Endo B|cytokeratin endo B|cytokeratin-18|keratin D|keratin complex 1, acidic, gene 18|keratin, type I cytoskeletal 18|keratin-18 |
Swissprots | Q3TIX1 Q3TJW7 Q61766 P05784 Q3TJH6 |
Accessions | AAA37552 CAA68365 EDL04011 P05784 AK145413 BAE26424 AK167072 BAE39232 AK167265 BAE39378 AK167432 BAE39519 AK167469 BAE39553 AK167676 BAE39725 AW539037 BC020474 BC089022 AAH89022 CV561123 M11686 AAA39390 M36376 AAA39373 NM_010664 NP_034794 |
Function | When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:17213200}. |
Subcellular Location | Nucleus matrix {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2416755, ECO:0000269|PubMed:2454868, ECO:0000269|PubMed:7504637}. |
Cytokeratin 18 CRISPR/Cas9 KO Plasmid (m) - sc-421343 from Santa Cruz Biotechnology
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Cytokeratin 18 HDR Plasmid (m) - sc-421343-HDR from Santa Cruz Biotechnology
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Cytokeratin 18 Double Nickase Plasmid (m) - sc-421343-NIC from Santa Cruz Biotechnology
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Cytokeratin 18 Double Nickase Plasmid (m2) - sc-421343-NIC-2 from Santa Cruz Biotechnology
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Cytokeratin 18 CRISPR Activation Plasmid (m) - sc-421343-ACT from Santa Cruz Biotechnology
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Cytokeratin 18 CRISPR Activation Plasmid (m2) - sc-421343-ACT-2 from Santa Cruz Biotechnology
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Cytokeratin 18 Lentiviral Activation Particles (m) - sc-421343-LAC from Santa Cruz Biotechnology
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Cytokeratin 18 Lentiviral Activation Particles (m2) - sc-421343-LAC-2 from Santa Cruz Biotechnology
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Cytokeratin 18 siRNA (m2) - sc-43287 from Santa Cruz Biotechnology
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Cytokeratin 18 shRNA Plasmid (m2) - sc-43287-SH from Santa Cruz Biotechnology
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Cytokeratin 18 shRNA (m2) Lentiviral Particles - sc-43287-V from Santa Cruz Biotechnology
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Cytokeratin 18 siRNA (m) - sc-45406 from Santa Cruz Biotechnology
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Cytokeratin 18 shRNA Plasmid (m) - sc-45406-SH from Santa Cruz Biotechnology
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Cytokeratin 18 shRNA (m) Lentiviral Particles - sc-45406-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU030291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34475 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34475 from Sigma-Aldrich
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KRT18 siRNA (Mouse) - CRM2267 from Cohesion Biosciences
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shRNA set against Mouse KRT18 (NM_010664.2) - SHH327299 from Creative biogene
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Mouse Cytokeratin 18 siRNA - orb281743 from Biorbyt
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KRT18 shRNA Plasmid (Mouse) - CHM2267 from Cohesion Biosciences
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