COMP

Gene Symbol COMP
Entrez Gene 1311
Alt Symbol EDM1, EPD1, MED, PSACH, THBS5
Species Human
Gene Type protein-coding
Description cartilage oligomeric matrix protein
Other Description TSP5|cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|pseudoachondroplasia (epiphyseal dysplasia 1, multiple)|thrombospondin-5
Swissprots Q8N4T2 Q16389 Q16388 Q2NL86 P49747 O14592 B4DKJ3
Accessions AAB35269 AAB35270 AAB86501 AAC83643 CCQ42965 EAW84735 EAW84736 EAW84737 P49747 AB086984 BAC53888 AK074508 BAC11031 AK223216 BAD96936 AK290595 BAF83284 AK296586 BAG59205 AK297798 BAG60137 AK297814 BAG60152 AU120397 BC033676 BC110847 AAI10848 BC125092 AAI25093 DQ893292 ABM84218 DQ896645 ABM87644 L32137 AAA57253 NM_000095 NP_000086
Function May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250}.
Subcellular Location Secreted, extracellular space, extracellular matrix.
Tissue Specificity Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. {ECO:0000269|PubMed:16542502}.
Top Pathways Focal adhesion, ECM-receptor interaction, Phagosome, Malaria, PI3K-Akt signaling pathway

Thrombospondin 5 (F-7) - sc-374660 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Thrombospondin 5 (F-7): sc-374660. Western blot analysis of Thrombospondin 5 expression in non-transfected: sc-117752 (A) and human Thrombospondin 5 transfected: sc-115080 (B) 293T whole cell lysates.

Thrombospondin 5 (H-90) - sc-32878 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Thrombospondin 5 (H-90): sc-32878. Western blot analysis of Thrombospondin 5 expression in non-transfected: sc-117752 (A) and human Thrombospondin 5 transfected: sc-115080 (B) 293T whole cell lysates.

Thrombospondin 5 (E-20) - sc-25163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Thrombospondin 5 (E-20): sc-25163. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing membrane and cytoplasmic staining of decidual cells.

Thrombospondin 5 (644A8D5) - sc-33696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Thrombospondin 5 (644A8D5): sc-33696. Western blot analysis of human (A) and bovine (B) Thrombospondin 5.

Thrombospondin 5 (N-15) - sc-25162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Thrombospondin 5 (MA37C94) - sc-59941 from Santa Cruz Biotechnology

Prices $279.00
Sizes 1000 µl supernatant
Host Rat
Clonality Monoclonal
Thrombospondin 5 (MA37C94): sc-59941. Western blot analysis of Thrombospondin 5 expression in non-transfected: sc-117752 (A) and human Thrombospondin 5 transfected: sc-115080 (B) 293T whole cell lysates.

Anti-COMP antibody - ab28400 from Abcam

Host Chicken
Clonality Polyclonal

Anti-COMP antibody - ab42225 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-COMP antibody (ab42225) at 1/1000 dilution + Human COMP full length protein (ab104358) at 0.01 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.Exposure time :  2 minutes

Anti-COMP antibody - ab91354 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-COMP antibody (ab91354) at 1/100 dilution (temperature) + Jurkat cell lysate at 35 µg

Anti-COMP antibody [EPR6289(2)] - ab128893 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR6289(2)
ICC/IF image of ab128893 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab128893 at 1/750 dilution overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-COMP antibody [MA37C94 (HC484D1)] - ab11056 from Abcam

Prices $378.00
Sizes 1 ml
Host Rat
Clonality Monoclonal
Clone MA37C94 (HC484D1)

Anti-COMP antibody [MM0702-3S37] - ab201556 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0702-3S37

Anti-COMP / THBS5 Antibody (Internal, clone MA37C94 (HC484D1)) - LS-C11538 from LifeSpan Bioscience

Host Rat
Clonality Monoclonal

Anti-COMP / THBS5 Antibody - LS-C79693 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COMP / THBS5 Antibody - LS-C122806 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-COMP / THBS5 Antibody - LS-C125386 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-COMP / THBS5 Antibody - LS-C122807 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-COMP / THBS5 Antibody (C-Terminus) - LS-C128267 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COMP / THBS5 Antibody - LS-C128268 from LifeSpan Bioscience

Host Chicken
Clonality Polyclonal

Anti-COMP / THBS5 Antibody - LS-C128269 from LifeSpan Bioscience

Host Chicken
Clonality Polyclonal

Anti-COMP / THBS5 Antibody - LS-C144593 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COMP / THBS5 Antibody - LS-C122808 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-COMP / THBS5 Antibody - LS-C144592 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COMP / THBS5 Antibody (Internal, AP) - LS-C276408 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COMP / THBS5 Antibody - LS-C153287 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Search more