COMP

Gene Symbol COMP
Entrez Gene 1311
Alt Symbol EDM1, EPD1, MED, PSACH, THBS5
Species Human
Gene Type protein-coding
Description cartilage oligomeric matrix protein
Other Description TSP5|cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|pseudoachondroplasia (epiphyseal dysplasia 1, multiple)|thrombospondin-5
Swissprots Q8N4T2 Q16389 Q16388 Q2NL86 P49747 O14592 B4DKJ3
Accessions AAB35269 AAB35270 AAB86501 AAC83643 CCQ42965 EAW84735 EAW84736 EAW84737 P49747 AB086984 BAC53888 AK074508 BAC11031 AK223216 BAD96936 AK290595 BAF83284 AK296586 BAG59205 AK297798 BAG60137 AK297814 BAG60152 AU120397 BC033676 BC110847 AAI10848 BC125092 AAI25093 DQ893292 ABM84218 DQ896645 ABM87644 L32137 AAA57253 NM_000095 NP_000086
Function May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250}.
Subcellular Location Secreted, extracellular space, extracellular matrix.
Tissue Specificity Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. {ECO:0000269|PubMed:16542502}.
Top Pathways Focal adhesion, ECM-receptor interaction, Phagosome, Malaria, PI3K-Akt signaling pathway

Thrombospondin 5 CRISPR/Cas9 KO Plasmid (h) - sc-402797 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Thrombospondin 5 HDR Plasmid (h) - sc-402797-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Thrombospondin 5 Double Nickase Plasmid (h) - sc-402797-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Thrombospondin 5 Double Nickase Plasmid (h2) - sc-402797-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Thrombospondin 5 CRISPR Activation Plasmid (h) - sc-402797-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Thrombospondin 5 CRISPR Activation Plasmid (h2) - sc-402797-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Thrombospondin 5 Lentiviral Activation Particles (h) - sc-402797-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Thrombospondin 5 Lentiviral Activation Particles (h2) - sc-402797-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Thrombospondin 5 siRNA (h) - sc-43195 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Thrombospondin 5 shRNA Plasmid (h) - sc-43195-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Thrombospondin 5 shRNA (h) Lentiviral Particles - sc-43195-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COMP/Thrombospondin-5 RNAi - H00001311-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU144221 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6423 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6423 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

COMP siRNA (Human) - CRH0923 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COMP - MBS8218287 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COMP (NM_000095.2) - SHH267677 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human COMP(NM_000095.2) - SHG192059 from Creative biogene

Category siRNA
Species Reactivities Human

Human COMP siRNA - orb261425 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COMP shRNA Plasmid (Human) - CHH0923 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COMP miRNA 3'UTR clone - MiUTR1H-02345 from Creative biogene

Species Reactivities Human
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