CACNA1F
| Gene Symbol | CACNA1F |
|---|---|
| Entrez Gene | 778 |
| Alt Symbol | AIED, COD3, COD4, CORDX, CORDX3, CSNB2, CSNB2A, CSNBX2, Cav1.4, Cav1.4alpha1, JM8, JMC8, OA2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, L type, alpha 1F subunit |
| Other Description | voltage-dependent L-type calcium channel subunit alpha-1F|voltage-gated calcium channel subunit alpha Cav1.4 |
| Swissprots | O60840 O43901 A6NI29 F5CIQ9 Q9UHB1 O95226 |
| Accessions | AAB92359 CAA06916 EAW50677 EAW50678 EAW50679 EAW50680 EAW50681 EAW50682 EAW50683 O60840 AA019975 AF067227 AAD03587 AF201304 AAF15290 AJ224874 CAA12175 BM931932 JF701915 AED89557 XM_011543983 XP_011542285 NM_001256789 NP_001243718 NM_001256790 NP_001243719 NM_005183 NP_005174 |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expression in skeletal muscle and retina. {ECO:0000269|PubMed:10873387}. |
| Top Pathways | Alzheimer's disease, Arrhythmogenic right ventricular cardiomyopathy (ARVC), cAMP signaling pathway, MAPK signaling pathway, Calcium signaling pathway |
L-type Ca ++ CP α1F CRISPR/Cas9 KO Plasmid (h) - sc-416338 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F HDR Plasmid (h) - sc-416338-HDR from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F Double Nickase Plasmid (h) - sc-416338-NIC from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F Double Nickase Plasmid (h2) - sc-416338-NIC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F CRISPR Activation Plasmid (h) - sc-416338-ACT from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F CRISPR Activation Plasmid (h2) - sc-416338-ACT-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F Lentiviral Activation Particles (h) - sc-416338-LAC from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F Lentiviral Activation Particles (h2) - sc-416338-LAC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F siRNA (h) - sc-42692 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F shRNA Plasmid (h) - sc-42692-SH from Santa Cruz Biotechnology
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L-type Ca ++ CP α1F shRNA (h) Lentiviral Particles - sc-42692-V from Santa Cruz Biotechnology
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Cav1.4 RNAi - H00000778-R01 from Novus Biologicals
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MISSION® esiRNA - EHU156011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2270 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2270 from Sigma-Aldrich
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CACNA1F siRNA (Human) - CRH0543 from Cohesion Biosciences
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CACNA1F - MBS8236887 from MyBioSource
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shRNA set against Human CACNA1F (NM_005183.2) - SHH253309 from Creative biogene
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shRNA set against Human CACNA1F(NM_005183.2) - SHG133135 from Creative biogene
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Human CACNA1F siRNA - orb261045 from Biorbyt
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CACNA1F shRNA Plasmid (Human) - CHH0543 from Cohesion Biosciences
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CACNA1F miRNA 3'UTR clone - MiUTR1H-01594 from Creative biogene
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