ACD
| Gene Symbol | ACD |
|---|---|
| Entrez Gene | 65057 |
| Alt Symbol | PIP1, PTOP, TINT1, TPP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adrenocortical dysplasia homolog (mouse) |
| Other Description | POT1 and TIN2 organizing protein|POT1 and TIN2-interacting protein|TIN2 interacting protein 1|adrenocortical dysplasia protein homolog |
| Swissprots | Q9H8F9 Q562H5 Q96AP0 |
| Accessions | AAX82621 EAW83154 EAW83155 Q96AP0 AF070535 AK023726 BAB14658 AK125623 AK301090 BAG62692 AY502940 AAS80318 BC016904 AAH16904 DB040017 XM_005256115 XP_005256172 XR_429727 XR_429728 NM_001082486 NP_001075955 NM_001082487 NP_001075956 NM_022914 NP_075065 |
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15181449}. Chromosome, telomere {ECO:0000269|PubMed:15181449}. |
ACD CRISPR/Cas9 KO Plasmid (h) - sc-406237 from Santa Cruz Biotechnology
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ACD HDR Plasmid (h) - sc-406237-HDR from Santa Cruz Biotechnology
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ACD Double Nickase Plasmid (h) - sc-406237-NIC from Santa Cruz Biotechnology
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ACD Double Nickase Plasmid (h2) - sc-406237-NIC-2 from Santa Cruz Biotechnology
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ACD CRISPR Activation Plasmid (h) - sc-406237-ACT from Santa Cruz Biotechnology
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ACD CRISPR Activation Plasmid (h2) - sc-406237-ACT-2 from Santa Cruz Biotechnology
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ACD Lentiviral Activation Particles (h) - sc-406237-LAC from Santa Cruz Biotechnology
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ACD Lentiviral Activation Particles (h2) - sc-406237-LAC-2 from Santa Cruz Biotechnology
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ACD siRNA (h) - sc-93019 from Santa Cruz Biotechnology
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ACD shRNA Plasmid (h) - sc-93019-SH from Santa Cruz Biotechnology
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ACD shRNA (h) Lentiviral Particles - sc-93019-V from Santa Cruz Biotechnology
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ACD RNAi - H00065057-R01 from Novus Biologicals
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ACD RNAi - H00065057-R02 from Novus Biologicals
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ACD RNAi - H00065057-R03 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN2714 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2714 from Sigma-Aldrich
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ACD siRNA (Human) - CRJ2169 from Cohesion Biosciences
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ACD - MBS8233512 from MyBioSource
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ACD CRISPR/Cas9 KO Plasmid (h2) - sc-406237-KO-2 from Santa Cruz Biotechnology
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ACD HDR Plasmid (h2) - sc-406237-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ACD (NM_022914.2) - SHH230194 from Creative biogene
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shRNA set against Human ACD(NM_022914.2) - SHG029125 from Creative biogene
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shRNA set against Human ACD(NM_001082486.1) - SHG029143 from Creative biogene
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shRNA set against Human ACD(NM_001082487.1) - SHG029179 from Creative biogene
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Human ACD siRNA - orb272670 from Biorbyt
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