AKR1A1

Gene Symbol AKR1A1
Entrez Gene 10327
Alt Symbol ALDR1, ALR, ARM, DD3, HEL-S-6
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member A1 (aldehyde reductase)
Other Description HEL-S-165mP|alcohol dehydrogenase|alcohol dehydrogenase [NADP(+)]|aldehyde reductase|aldo-keto reductase family 1 member A1|dihydrodiol dehydrogenase 3|epididymis secretory protein Li 6|epididymis secretory sperm binding protein Li 165mP
Swissprots Q6IAZ4 P14550 D3DQ04 A8KAL8
Accessions AAB92369 AAF01260 EAX06970 EAX06971 EAX06972 EAX06973 EAX06974 P14550 AK293083 BAF85772 AK307068 AK307237 AK307288 AK311175 AU142853 BC000670 AAH00670 BC005394 AAH05394 BC033287 BI549149 BT007003 AAP35649 BU631634 CR457010 CAG33291 CX788871 DA550374 DA871469 DQ890682 ABM81608 DQ893770 ABM84696 DQ893865 ABM84791 EU668319 ACF94472 EU794588 ACJ13642 J04794 AAA51711 XM_011540491 XP_011538793 XM_011540492 XP_011538794 XR_946517 NM_001202414 NP_001189343 NM_006066 NP_006057 NM_153326 NP_697021 NM_001202413 NP_001189342
Function Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838}.
Tissue Specificity Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097}.
Top Pathways Glycolysis / Gluconeogenesis, Pentose and glucuronate interconversions, Glycerolipid metabolism, Degradation of aromatic compounds

AKR1A1 (B-9) - sc-365078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKR1A1 (B-9): sc-365078. Western blot analysis of AKR1A1 expression in non-transfected 293T: sc-117752 (A), human AKR1A1 transfected 293T: sc-174231 (B) and Hep G2 (C) whole cell lysates.

AKR1A1 (B-10) - sc-374204 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKR1A1 (B-10): sc-374204. Western blot analysis of AKR1A1 expression in non-transfected 293T: sc-117752 (A), human AKR1A1 transfected 293T: sc-174231 (B) and Hep G2 (C) whole cell lysates.

AKR1A1 (C-13) - sc-161328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AKR1A1 (C-13): sc-161328. Western blot analysis of AKR1A1 expression in non-transfected 293T: sc-117752 (A), human AKR1A1 transfected 293T: sc-174231 (B) and Hep G2 (C) whole cell lysates.

AKR1A1 (E-9) - sc-271723 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKR1A1 (E-9): sc-271723. Western blot analysis of AKR1A1 expression in HeLa whole cell lysate.

AKR1A1 (G-13) - sc-161329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AKR1A1 (G-13): sc-161329. Western blot analysis of AKR1A1 expression in non-transfected: sc-117752 (A) and human AKR1A1 transfected: sc-174231 (B) 293T whole cell lysates.

AKR1A1 (H-115) - sc-135112 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AKR1A1 (H-115): sc-135112. Western blot analysis of AKR1A1 expression in non-transfected: sc-117752 (A) and human AKR1A1 transfected: sc-174231 (B) 293T whole cell lysates and human kidney (C) and human liver (D) tissue extracts.

AKR1A1 (3B08) - sc-100500 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
AKR1A1 (3B08): sc-100500. Western blot analysis of AKR1A1 expression in HL-60 whole cell lysate.

Anti-AKR1A1 antibody - ab11802 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-AKR1A1 antibody (ab11802) at 0.1 µg/ml + Human Liver lysate (in RIPA buffer) at 35 µg

Anti-AKR1A1 antibody - ab175258 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid cancer tissue labelling AKR1A1 with ab175258 at 1/400. Magnification: 200x.

Anti-AKR1A1 antibody - ab84325 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-AKR1A1 antibody (ab84325) at 1/1000 dilution + Human fetal liver lysate

Anti-AKR1A1 antibody - ab125878 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKR1A1 antibody (ab125878) at 1/1000 dilutionLane 1 : A549 whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-AKR1A1 antibody - ab56635 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
AKR1A1 antibody (ab56635) used in immunohistochemistry at 5ug/ml on formalin fixed and paraffin embedded human tonsil.

Anti-AKR1A1 antibody [9F1] - ab124347 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9F1
All lanes : Anti-AKR1A1 antibody [9F1] (ab124347) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY AKR1A1 cDNALysates/proteins at 5 µg per lane.

Anti-AKR1A1 antibody - C-terminal - ab71228 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AKR1A1 antibody - C-terminal (ab71228) at 1/60 dilution + Y79 cell line lysates at 35 µg

Anti-Alcohol Dehydrogenase antibody (Biotin) - ab35972 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Alcohol Dehydrogenase antibody (HRP) - Azide free - ab34575 from Abcam

Prices $359.00
Sizes 10 mg
Host Rabbit
Clonality Polyclonal

Anti-AKR1A1 Antibody (clone 1A11-2A4) - LS-C133637 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A11-2A4
Immunoperoxidase of monoclonal antibody to AKR1A1 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 0.75 ug/ml]

Anti-AKR1A1 Antibody (C-Terminus) - LS-C347627 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1A1 Antibody - LS-C192341 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of AKR1A1 pAb in extracts from Y79 and Jurkat cells.

Anti-AKR1A1 Antibody (N-Terminus) - LS-C345758 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of AKR1A1 Antibody with human HepG2 Whole Cell lysate.

Anti-AKR1A1 Antibody (clone 4G6) - LS-C114885 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G6
IHC of paraffin-embedded Adenocarcinoma of ovary tissue using anti-AKR1A1 mouse monoclonal antibody. (Dilution 1:50).

Anti-AKR1A1 Antibody - LS-C331236 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human endometrial cancer using AKR1A1 antibody at dilution of 1:400 (200x lens).

Anti-AKR1A1 Antibody - LS-C136832 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1A1 Antibody (C-Terminus) - LS-C151742 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AKR1A1 antibody Western Blot of THP-1.

Anti-AKR1A1 Antibody - LS-C137236 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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