UBC
| Gene Symbol | UBC |
|---|---|
| Entrez Gene | 7316 |
| Alt Symbol | HMG20 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin C |
| Other Description | polyubiquitin-C |
| Swissprots | Q9UEF2 Q9UEK8 P62988 P0CG48 Q6LBL4 Q6LDU5 Q8WYN8 Q9UPK7 Q9BX98 Q9BWD6 Q9UEG1 |
| Accessions | BAA09860 BAA23486 BAC56951 BAM77032 BAM77033 BAM77034 BAM77035 BAM77036 BAM77037 EAW98463 EAW98464 EAW98465 EAW98466 P0CG48 AB009010 BAA23632 AB209782 BAD93019 AF052164 AK026846 AK056939 BAB71316 AK092983 AK097415 AK098827 AK129749 AK291539 BAF84228 AL117514 CAB55973 AW069329 AY732488 AAV33127 AY819759 AAV68344 BC000449 BC008955 AAH08955 BC014880 AAH14880 BC039193 AAH39193 BC080583 AAH80583 BC093445 BE873233 BF793240 BU195276 DB077241 DC395997 M17597 AAA36787 M26880 AAA36789 NM_021009 NP_066289 |
| Function | Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac |
| Subcellular Location | Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Top Pathways | PPAR signaling pathway |
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