| Gene Symbol |
FPGS
|
| Entrez Gene |
2356
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
folylpolyglutamate synthase
|
| Other Description |
folylpoly-gamma-glutamate synthetase|folylpolyglutamate synthase, mitochondrial|tetrahydrofolate synthase|tetrahydrofolylpolyglutamate synthase
|
| Swissprots |
Q6P2P6 Q5JU19 B7Z2Z3 F5H0K6 B3KPW4 Q05932 Q5JU22
|
| Accessions |
AAA85815 AAL08404 AAL08405 CCQ43291 EAW87698 EAW87699 EAW87700 EAW87701 Q05932 AK056920 BAG51826 AK295309 BAH12029 AK315523 BAG37904 AY007210 AY007211 AAL08406 AY007212 BC007121 BC009901 BC064393 AAH64393 BE302497 BF345926 BG328181 BT006639 AAP35285 CB854085 DA987755 DC365273 M98045 AAA35852 XM_005251864 XP_005251921 XM_011518437 XP_011516739 XM_011518438 XP_011516740 XM_011518439 XP_011516741 XR_242581 XR_242582 NM_001018078 NP_001018088 NM_001288803 NP_001275732 NM_004957 NP_004948 NR_110170
|
| Function |
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.
|
| Subcellular Location |
Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.
|
| Top Pathways |
Folate biosynthesis
|