FPGS

Gene Symbol FPGS
Entrez Gene 2356
Alt Symbol -
Species Human
Gene Type protein-coding
Description folylpolyglutamate synthase
Other Description folylpoly-gamma-glutamate synthetase|folylpolyglutamate synthase, mitochondrial|tetrahydrofolate synthase|tetrahydrofolylpolyglutamate synthase
Swissprots Q6P2P6 Q5JU19 B7Z2Z3 F5H0K6 B3KPW4 Q05932 Q5JU22
Accessions AAA85815 AAL08404 AAL08405 CCQ43291 EAW87698 EAW87699 EAW87700 EAW87701 Q05932 AK056920 BAG51826 AK295309 BAH12029 AK315523 BAG37904 AY007210 AY007211 AAL08406 AY007212 BC007121 BC009901 BC064393 AAH64393 BE302497 BF345926 BG328181 BT006639 AAP35285 CB854085 DA987755 DC365273 M98045 AAA35852 XM_005251864 XP_005251921 XM_011518437 XP_011516739 XM_011518438 XP_011516740 XM_011518439 XP_011516741 XR_242581 XR_242582 NM_001018078 NP_001018088 NM_001288803 NP_001275732 NM_004957 NP_004948 NR_110170
Function Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.
Subcellular Location Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix.
Top Pathways Folate biosynthesis

Human Folylpolyglutamate synthase protein fragment - ab158464 from Abcam

Category Protein
Source Wheat germ
Species Human
ab158464 on a 12.5% SDS-PAGE stained with Coomassie Blue.

FPGS Antibody Blocking Peptide - LS-E23137 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

FPGS Antibody Blocking Peptide - LS-E8578 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human FPGS Protein - H00002356-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

FPGS-Antibody-Center-Blocking-Peptide - BP6975c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

FPGS - H00002356-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

FPGS - H00002356-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

FPGS fusion protein - ag9147 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Folylpolyglutamate Synthase, Mitochondrial (FPGS) - RPC485Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

FPGS Peptide, Human - M34GP05885H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Folylpolyglutamate synthase (fgs), Recombinant Protein - MBS1012455 from MyBioSource

Category Protein
Prices $1,205.00, $1,205.00, $1,425.00, $1,425.00, $1,945.00, $1,945.00, $2,410.00, $2,410.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Lactobacillus

Folylpolyglutamate synthase (folC), Recombinant Protein - MBS1213885 from MyBioSource

Category Protein
Prices $1,215.00, $1,215.00, $1,435.00, $1,435.00, $1,965.00, $1,965.00, $2,430.00, $2,430.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Haemophilus

FPGS Recombinant Protein Antigen - NBP2-48965PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E. coli
Species Human
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