ADRBK1

Gene Symbol	ADRBK1
Entrez Gene	156
Alt Symbol	BARK1, BETA-ARK1, GRK2
Species	Human
Gene Type	protein-coding
Description	adrenergic, beta, receptor kinase 1
Other Description	G-protein coupled receptor kinase 2|beta-ARK-1|beta-adrenergic receptor kinase 1
Swissprots	P25098 B0ZBE1 Q6GTT3 Q13837
Accessions	AAB60689 ACA05909 EAW74581 EAW74582 P25098 AB209588 BAD92825 AI888604 AK131506 BC037963 AAH37963 BC090863 AAH90863 DN989901 DQ891148 ABM82074 DQ894328 ABM85254 M80776 AAA58391 X61157 CAA43470 XM_011544773 XP_011543075 XR_949796 NM_001619 NP_001610
Function	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. {ECO:0000269|PubMed:19306925}.
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}.
Tissue Specificity	Expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:10085131}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Glutamatergic synapse, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human GRK2 full length protein - ab125620 from Abcam Category Protein Prices $239.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

GRK2 peptide - ab90825 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human GRK2 full length protein - ab157863 from Abcam Category Protein Source Wheat germ Species Human

Human GRK2 peptide - ab48046 from Abcam Category Peptide Species Human

ADRBK1 / GRK2 Antibody Blocking Peptide - LS-E26047 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ADRBK1 / GRK2 Antibody Blocking Peptide - LS-E18650 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ADRBK1 / GRK2 Antibody Blocking Peptide - LS-E18651 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GRK2 Protein - H00000156-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GRK2 Peptide - P2087 from Novus Biologicals Category Peptide Species Human

ADRBK1-Antibody-C-term-Blocking-peptide - BP7004a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GRK2 blocking peptide - GTX89353-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant human Beta-adrenergic receptor kinase 1 (OPCA00360) - OPCA00360 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human ADRBK1 protein - orb245056 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

GRK2 peptide - orb72761 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

ADRBK1 Blocking Peptide - 33R-4058 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ADRBK1 Blocking Peptide - 33R-7058 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRK2 (phospho-Ser29) Blocking Peptide - abx062222 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

GRK2 Blocking Peptide - abx062223 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig

Human ADRbK1 Protein - abx065177 from Abbexa Category Protein Source E.coli Species Human

GRK2 Peptide - AC21-0875-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Beta-ARK-1 / ADRBK1 - H00000156-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Beta-ARK-1 / ADRBK1 - H00000156-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Beta-ARK-1 / ADRBK1 - P5495 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

GRK2 Peptide - 45-711P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

ADRBK1 fusion protein - Ag5071 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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