Gene Symbol | Vcam1 |
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Entrez Gene | 22329 |
Alt Symbol | CD106, Vcam-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | vascular cell adhesion molecule 1 |
Other Description | V-CAM 1|vascular cell adhesion protein 1 |
Swissprots | P29533 |
Accessions | AAA16920 AAA16921 AAA80010 AAA80011 AAA80012 AAA80013 AAA80014 AAA80015 AAA80016 AAB60659 AAB60660 AAB60661 AAB60662 AAB60663 AAB60664 AAB88576 EDL12388 EDL12389 P29533 AK016465 AK030195 BAC26834 AK078081 AK085320 AK143401 BAE25364 AK162954 BAE37132 AK169722 BC011159 AAH11159 BC029823 AAH29823 CT010373 CAJ18580 L08431 AAA40546 L12541 AAC37607 M84487 AAA40545 U12884 AAA64832 X67783 CAA47989 NM_011693 NP_035823 |
Function | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow. {ECO:0000269|PubMed:1713592}. |
Top Pathways | Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Malaria, African trypanosomiasis, HTLV-I infection |
VCAM-1 CRISPR/Cas9 KO Plasmid (m) - sc-423659 from Santa Cruz Biotechnology
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VCAM-1 HDR Plasmid (m) - sc-423659-HDR from Santa Cruz Biotechnology
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VCAM-1 Double Nickase Plasmid (m) - sc-423659-NIC from Santa Cruz Biotechnology
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VCAM-1 Double Nickase Plasmid (m2) - sc-423659-NIC-2 from Santa Cruz Biotechnology
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VCAM-1 CRISPR Activation Plasmid (m) - sc-423659-ACT from Santa Cruz Biotechnology
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VCAM-1 CRISPR Activation Plasmid (m2) - sc-423659-ACT-2 from Santa Cruz Biotechnology
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VCAM-1 Lentiviral Activation Particles (m) - sc-423659-LAC from Santa Cruz Biotechnology
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VCAM-1 Lentiviral Activation Particles (m2) - sc-423659-LAC-2 from Santa Cruz Biotechnology
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VCAM-1 siRNA (m) - sc-36810 from Santa Cruz Biotechnology
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VCAM-1 shRNA Plasmid (m) - sc-36810-SH from Santa Cruz Biotechnology
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VCAM-1 shRNA (m) Lentiviral Particles - sc-36810-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU009991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN44094 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44094 from Sigma-Aldrich
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VCAM1 siRNA (Mouse) - CRM4379 from Cohesion Biosciences
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VCAM1 - MBS8215218 from MyBioSource
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shRNA set against Mouse VCAM1 (NM_011693.3) - SHH442424 from Creative biogene
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Mouse VCAM1 siRNA - orb283855 from Biorbyt
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VCAM1 shRNA Plasmid (Mouse) - CHM4379 from Cohesion Biosciences
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