H2AFZ

Gene Symbol H2AFZ
Entrez Gene 3015
Alt Symbol H2A.Z-1, H2A.z, H2A/z, H2AZ
Species Human
Gene Type protein-coding
Description H2A histone family, member Z
Other Description H2AZ histone|histone H2A.Z
Swissprots Q6I9U0 B2RD56 P0C0S5
Accessions AAC61625 AAG25670 AAY41013 CAC10733 CAC10748 EAX06118 P0C0S5 AK056803 AK315413 BAG37803 AY597416 BC018002 AAH18002 BC020936 AAH20936 BC032524 BC039005 BC103743 AAI03744 CD685635 CR457415 CAG33696 D28450 BAA05816 DQ893216 ABM84142 DQ896545 ABM87544 M37583 AAA35984 X52317 CAA36553 NM_002106 NP_002097
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269|PubMed:15878876}.
Subcellular Location Nucleus. Chromosome.
Top Pathways Systemic lupus erythematosus, Alcoholism

Histone H2A.Z Antibody - 2718 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa, NIH/3T3, H-4-II-E and COS cell lysates, in addition to 10 ng of recombinant H2A (rH2A) and H2A.Z (rH2A.Z) protein, using Histone H2A.Z Antibody #2718 (upper) and Histone H2A Antibody II #2578 (lower).

Histone H2A.Z/H2A.F/Z (FL-128) - sc-67218 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Histone H2A.Z/H2A.F/Z (FL-128): sc-67218. Immuno-fluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

Histone H2A.Z/H2A.F/Z (G-13) - sc-54387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Histone H2A.Z/H2A.F/Z (N-15) - sc-54388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Histone H2A.Z (acetyl K4 + K7 + K11) antibody - ChIP Grade - ab18262 from Abcam

Prices $401.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
ChIP analysis of Acetyl-H2A.Z at the p21 transcription start site with or without the HDAC inhibitor TSA (50ng/ml). Chromatin was prepared from MDA-MB231 cells. Cells were fixed with formaldehyde for 10min. Samples were sonicated to generate DNA fragments between 500 and 700 bp. The ChIP was performed with 50µg of chromatin, fragments were immunoprecipitated using 2µg of antibody ab18262, and an HA antibody was used as control. The precipitated DNA was amplified by real-time PCR, with primer sets designed to amplify the promoter and the coding region of the p21 gene.  

Anti-Histone H2A.Z antibody - ab135146 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Histone H2A.Z antibody [EPR6171(2)(B] - Nuclear Marker - ab150402 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6171(2)(B
All lanes : Anti-Histone H2A.Z antibody [EPR6171(2)(B] - Nuclear Marker (ab150402) at 1/1000 dilutionLane 1 : Neuro2a cell lysateLane 2 : HeLa cell lysateLane 3 : HepG2 cell lysateLane 4 : PC12 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-Histone H2A.Z antibody [EPR6171(2)(B] - Nuclear Marker (Alexa Fluor® 488) - ab185046 from Abcam

Prices $431.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6171(2)(B
Overlay histogram showing HeLa cells stained with ab185046 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab185046, 1/500 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 488 used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control.Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Histone H2A.Z antibody [EPR6172] - ab124793 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6172
All lanes : Anti-Histone H2A.Z antibody [EPR6172] (ab124793) at 1/1000 dilutionLane 1 : C6 lysates Lane 2 : Raw 264.7 lysates Lane 3 : PC-12 lysates Lane 4 : NIH/3T3 lysates Lane 5 : HeLa lysates Lane 6 : HepG2 lysates Lane 7 : Human thymus lysates Lysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Histone H2A.Z antibody - ChIP Grade - ab18263 from Abcam

Prices $384.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
All lanes : Anti-Histone H2A.Z antibody - ChIP Grade (ab18263)Lane 1 : Butyrate-treated HeLa histonesLane 2 : 15-day embryo chicken erythrocyte histonesLane 3 : Recombinant H2A.ZLane 4 : Butyrate-treated HeLa histonesLane 5 : 15-day embryo chicken erythrocyte histonesLane 6 : Recombinant H2A.Z

Anti-Histone H2A.Z antibody - ChIP Grade - ab97966 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Histone H2A.Z antibody - ChIP Grade (ab97966) at 1/3000 dilutionLane 1 : MOLT4 whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Histone H2A.Z antibody - ChIP Grade - ab97941 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Histone H2A.Z antibody - ChIP Grade (ab97941) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-H2AFZ / H2A.z Antibody (Internal) - LS-C153462 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa59-86, AP) - LS-C258220 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa59-86, APC) - LS-C258221 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa59-86, Biotin) - LS-C258222 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa59-86, FITC) - LS-C258223 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa59-86, Azide-free, HRP) - LS-C258224 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa59-86, PE) - LS-C258225 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (C-Terminus) - LS-C145335 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
H2AFZ / Histone H2A. Z antibody LS-C145335 Western blot of HeLa Cell lysate. Antibody concentration 1 ug/ml.

Anti-H2AFZ / H2A.z Antibody (N-Terminus) - LS-C145623 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
H2AFZ / Histone H2A. Z antibody LS-C145623 Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.

Anti-H2AFZ / H2A.z Antibody (aa2-128, Biotin) - LS-C300493 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa2-128, FITC) - LS-C302908 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa66-94) - LS-C321859 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-H2AFZ / H2A.z Antibody (aa2-128) - LS-C294373 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant H2AFZ / H2A.z.
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