| Gene Symbol |
H2AFZ
|
| Entrez Gene |
3015
|
| Alt Symbol |
H2A.Z-1, H2A.z, H2A/z, H2AZ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
H2A histone family, member Z
|
| Other Description |
H2AZ histone|histone H2A.Z
|
| Swissprots |
Q6I9U0 B2RD56 P0C0S5
|
| Accessions |
AAC61625 AAG25670 AAY41013 CAC10733 CAC10748 EAX06118 P0C0S5 AK056803 AK315413 BAG37803 AY597416 BC018002 AAH18002 BC020936 AAH20936 BC032524 BC039005 BC103743 AAI03744 CD685635 CR457415 CAG33696 D28450 BAA05816 DQ893216 ABM84142 DQ896545 ABM87544 M37583 AAA35984 X52317 CAA36553 NM_002106 NP_002097
|
| Function |
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269|PubMed:15878876}.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Top Pathways |
Systemic lupus erythematosus, Alcoholism
|
![Western Blot: Histone H2A.Z Overexpression Lysate (Adult Normal) [NBL1-11427] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Histone H2A.Z.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5441_Histone%2520H2A.Z%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11427-img0002.jpg)