Gene Symbol | Itgal |
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Entrez Gene | 16408 |
Alt Symbol | (p180), Cd11a, LFA-1, LFA-1A, Ly-15, Ly-21 |
Species | Mouse |
Gene Type | protein-coding |
Description | integrin alpha L |
Other Description | CD11 antigen-like family member A|alpha L integrin|integrin alpha-L|leukocyte adhesion glycoprotein LFA-1 alpha chain|leukocyte function-associated molecule 1 alpha chain|lymphocyte antigen 15|lymphocyte function associated antigen 1, alpha polypeptide |
Swissprots | P24063 |
Accessions | EDL17526 EDL17527 P24063 AF065901 AAD25884 AF065902 AAD25885 AK141575 BAE24744 AK152913 AK154115 AK155566 BAE33326 AK156251 BAE33641 AK169628 AK171389 BAE42429 AK172394 BAE42982 BC145094 AAI45095 BC145095 AAI45096 BC145096 AAI45097 BC145802 AAI45803 BY196102 JN986841 AEX14533 M60778 AAA39426 XM_006507393 XP_006507456 XM_011241683 XP_011239985 NM_001253872 NP_001240801 NM_001253873 NP_001240802 NM_001253874 NP_001240803 NM_008400 NP_032426 |
Function | Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Mice expressing a null mutation of the alpha-L subunit gene demonstrate impaired tumor rejection and impaired leukocytes recruitment. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Leukocytes. |
Top Pathways | Malaria, Rap1 signaling pathway, Epstein-Barr virus infection, HTLV-I infection, Rheumatoid arthritis |
Integrin αL (Y-17) - sc-6611 from Santa Cruz Biotechnology
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Integrin αL (I21/7) - sc-18847 from Santa Cruz Biotechnology
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Anti-CD11a antibody [121/7] - ab119356 from Abcam
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Anti-CD11a antibody [I21/7] - ab25383 from Abcam
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Anti-CD11a antibody [I21/7] (Biotin) - ab24951 from Abcam
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Anti-CD11a antibody [I21/7] (PE/Cy7 ®) - ab51220 from Abcam
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Anti-CD11a antibody [I21/7] (Phycoerythrin) - ab25500 from Abcam
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Anti-CD11a antibody [M17/4] - ab119878 from Abcam
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Anti-CD11a antibody [M17/4] - Low endotoxin, Azide free, prediluted - ab174592 from Abcam
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Integrin alpha L/CD11a Antibody (M17/4) - NBP1-41264 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) - NB100-77367 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (I21/7) - NBP1-27870 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (87-6F9) - NBP1-42196 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (121/7) - NBP2-22431 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (I21/7) [FITC] - NBP1-27871 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (M17/4) [FITC] - NBP1-41277 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (I21/7) [Biotin] - NBP1-27872 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) [DyLight 550] - NB100-77367R from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) [DyLight 488] - NB100-77367G from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) [DyLight 650] - NB100-77367C from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) [PerCP] - NB100-77367PCP from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) [DyLight 350] - NB100-77367UV from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) [DyLight 755] - NB100-77367IR from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) [Alexa Fluor (R) 700] - NB100-77367AF700 from Novus Biologicals
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Integrin alpha L/CD11a Antibody (2D7) [Alexa Fluor (R) 647] - NB100-77367AF647 from Novus Biologicals
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