| Gene Symbol |
Itgal
|
| Entrez Gene |
16408
|
| Alt Symbol |
(p180), Cd11a, LFA-1, LFA-1A, Ly-15, Ly-21
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
integrin alpha L
|
| Other Description |
CD11 antigen-like family member A|alpha L integrin|integrin alpha-L|leukocyte adhesion glycoprotein LFA-1 alpha chain|leukocyte function-associated molecule 1 alpha chain|lymphocyte antigen 15|lymphocyte function associated antigen 1, alpha polypeptide
|
| Swissprots |
P24063
|
| Accessions |
EDL17526 EDL17527 P24063 AF065901 AAD25884 AF065902 AAD25885 AK141575 BAE24744 AK152913 AK154115 AK155566 BAE33326 AK156251 BAE33641 AK169628 AK171389 BAE42429 AK172394 BAE42982 BC145094 AAI45095 BC145095 AAI45096 BC145096 AAI45097 BC145802 AAI45803 BY196102 JN986841 AEX14533 M60778 AAA39426 XM_006507393 XP_006507456 XM_011241683 XP_011239985 NM_001253872 NP_001240801 NM_001253873 NP_001240802 NM_001253874 NP_001240803 NM_008400 NP_032426
|
| Function |
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Mice expressing a null mutation of the alpha-L subunit gene demonstrate impaired tumor rejection and impaired leukocytes recruitment.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Leukocytes.
|
| Top Pathways |
Malaria, Rap1 signaling pathway, Epstein-Barr virus infection, HTLV-I infection, Rheumatoid arthritis
|