PECAM1

Gene Symbol	PECAM1
Entrez Gene	5175
Alt Symbol	CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM
Species	Human
Gene Type	protein-coding
Description	platelet/endothelial cell adhesion molecule 1
Other Description	CD31 antigen|platelet endothelial cell adhesion molecule
Swissprots	Q8TBH1 Q9NQS9 Q96RF5 Q9NQT2 Q9NPG9 P16284 A8K3S7 Q9NQT0 Q6LDA9 Q96RF6 D3DU31 Q9NQT1 Q9NP65 Q9NPB7
Accessions	AAA60057 EAW94207 EAW94208 P16284 AF281287 AAF91446 AF281288 AAF91447 AF281289 AAF91448 AF281290 AAF91449 AF281291 AAF91450 AF281292 AAF91451 AF281293 AAF91452 AF281294 AAF91453 AF281295 AAF91454 AF281296 AAF91455 AF281297 AAF91456 AF281298 AAF91457 AF281299 AAF91458 AF281300 AAF91459 AF281301 AAF91460 AF393676 AAK84009 AF393677 AAK84010 AF393678 AAK84011 AK091419 AK290692 BAF83381 AK303959 BAH14084 AK304166 BAH14122 BC022512 AAH22512 BC051822 AAH51822 BC062608 BG272085 DQ893644 ABM84570 JQ287500 AFA36630 M28526 AAA36429 M37780 AAA36186 S66450 AAB28645 X96849 XM_005276880 XP_005276937 XM_005276881 XP_005276938 XM_005276882 XP_005276939 XM_005276883 XP_005276940 XM_011524889 XP_011523191 XM_011524890 XP_011523192 NM_000442 NP_000433
Function	Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the ea
Subcellular Location	Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Tissue Specificity	Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level). {ECO:0000269|PubMed:12433657, ECO:0000269|PubMed:19342684}.
Top Pathways	Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Malaria

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD31 protein fragment - ab155607 from Abcam Category Protein Prices $465.00 Sizes 200 µg Source HEK 293 cells Species Human

CD31 peptide - ab93786 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CD31 full length protein - ab131797 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CD31 full length protein - ab131798 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CD31 peptide - ab32456 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CD31 protein fragment - ab129040 from Abcam Category Protein Prices $402.00 Sizes 50 µg Source HEK 293 cells Species Human

Human CD31 protein fragment - ab94370 from Abcam Category Protein Prices $235.00 Sizes 50 µg Source HEK 293 cells Species Human

Mouse CD31 peptide - ab155816 from Abcam Category Peptide Species Mouse

PECAM-1 / CD31 Antibody Blocking Peptide - LS-E601 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PECAM-1 / CD31 Antibody Blocking Peptide - LS-E8986 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD31/PECAM-1 Recombinant Protein - H00005175-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CD31/PECAM-1 Recombinant Protein - H00005175-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CD31-Antibody-C-term-Blocking-Peptide - BP7465b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Hemoglobin alpha Protein - GTX112750-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

PECAM-1 Recombinant Protein - GTX48164-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source Human Species Human

Recombinant Human CD31/PECAM-1, CF - ADP6-200 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Gln28-Lys601

CD31 Protein (OPPA01373) - OPPA01373 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human CD31 Protein (OPSA11769) - OPSA11769 from Aviva Systems Biology Category Protein Prices $440.00 Sizes 50 µg Species Human

Human CD31 protein - orb81007 from Biorbyt Category Protein Prices $323.00, $595.00, $1,139.00 Sizes 100 μg, 500 μg, 1 mg Source E.coli

CD31 peptide - orb72478 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

CD31 (phospho-Tyr713) Blocking Peptide - abx063065 from Abbexa Category Peptide Species Human, Mouse, Rat

CD31 Blocking Peptide - abx063066 from Abbexa Category Peptide Species Human, Mouse, Rat

Human PECAM1 Protein - abx068599 from Abbexa Category Protein Source E.coli Species Human

Human PECAM1 Protein - abx068602 from Abbexa Category Protein Source E.coli Species Human

CD31 / PECAM1 - H00005175-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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