| Gene Symbol |
PECAM1
|
| Entrez Gene |
5175
|
| Alt Symbol |
CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
platelet/endothelial cell adhesion molecule 1
|
| Other Description |
CD31 antigen|platelet endothelial cell adhesion molecule
|
| Swissprots |
Q8TBH1 Q9NQS9 Q96RF5 Q9NQT2 Q9NPG9 P16284 A8K3S7 Q9NQT0 Q6LDA9 Q96RF6 D3DU31 Q9NQT1 Q9NP65 Q9NPB7
|
| Accessions |
AAA60057 EAW94207 EAW94208 P16284 AF281287 AAF91446 AF281288 AAF91447 AF281289 AAF91448 AF281290 AAF91449 AF281291 AAF91450 AF281292 AAF91451 AF281293 AAF91452 AF281294 AAF91453 AF281295 AAF91454 AF281296 AAF91455 AF281297 AAF91456 AF281298 AAF91457 AF281299 AAF91458 AF281300 AAF91459 AF281301 AAF91460 AF393676 AAK84009 AF393677 AAK84010 AF393678 AAK84011 AK091419 AK290692 BAF83381 AK303959 BAH14084 AK304166 BAH14122 BC022512 AAH22512 BC051822 AAH51822 BC062608 BG272085 DQ893644 ABM84570 JQ287500 AFA36630 M28526 AAA36429 M37780 AAA36186 S66450 AAB28645 X96849 XM_005276880 XP_005276937 XM_005276881 XP_005276938 XM_005276882 XP_005276939 XM_005276883 XP_005276940 XM_011524889 XP_011523191 XM_011524890 XP_011523192 NM_000442 NP_000433
|
| Function |
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the ea
|
| Subcellular Location |
Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
|
| Tissue Specificity |
Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level). {ECO:0000269|PubMed:12433657, ECO:0000269|PubMed:19342684}.
|
| Top Pathways |
Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Malaria
|