| Gene Symbol |
Mettl14
|
| Entrez Gene |
210529
|
| Alt Symbol |
G430022H21Rik, mKIAA1627
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
methyltransferase like 14
|
| Other Description |
N6-adenosine-methyltransferase subunit METTL14|methyltransferase-like protein 14|snoRNA MBII-84
|
| Swissprots |
Q3UIK4 Q6ZPL2 Q80UR9
|
| Accessions |
EDL12301 EDL12302 EDL12303 EDL12304 Q3UIK4 AK083169 AK089949 AK129409 BAC98219 AK136652 AK146881 BAE27502 AK153810 AK190133 BC044899 BC052204 AAH52204 BE448358 BI990545 BM247306 NM_201638 NP_964000
|
| Function |
N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs. {ECO:0000269|PubMed:24394384}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:24394384}.
|