| Gene Symbol | Mettl14 |
|---|---|
| Entrez Gene | 210529 |
| Alt Symbol | G430022H21Rik, mKIAA1627 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | methyltransferase like 14 |
| Other Description | N6-adenosine-methyltransferase subunit METTL14|methyltransferase-like protein 14|snoRNA MBII-84 |
| Swissprots | Q3UIK4 Q6ZPL2 Q80UR9 |
| Accessions | EDL12301 EDL12302 EDL12303 EDL12304 Q3UIK4 AK083169 AK089949 AK129409 BAC98219 AK136652 AK146881 BAE27502 AK153810 AK190133 BC044899 BC052204 AAH52204 BE448358 BI990545 BM247306 NM_201638 NP_964000 |
| Function | N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs. {ECO:0000269|PubMed:24394384}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:24394384}. |
Recombinant Mouse Methyltransferase-like protein 14(Mettl14) - CSB-YP667575MO CSB-EP667575MO CSB-BP667575MO CSB-MP667575MO from Cusabio
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Recombinant Mouse METTL14 Protein - METTL14-9749M from Creative Biomart
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Methyltransferase-like protein 14 (Mettl14), Recombinant Protein - MBS1340265 from MyBioSource
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