DAPK1

Gene Symbol DAPK1
Entrez Gene 1612
Alt Symbol DAPK
Species Human
Gene Type protein-coding
Description death-associated protein kinase 1
Other Description DAP kinase 1
Swissprots Q1W5W0 Q6ZRZ3 P53355 B7ZLE7 Q9BTL8 Q68CP8 Q14CQ7 B7ZLD2
Accessions ABD96827 EAW62725 EAW62726 EAW62727 EAW62728 P53355 AA846231 AA854055 AB208871 BAD92108 AK127855 BAC87163 AK295119 BAG58146 AK296839 BAH12440 BC113660 AAI13661 BC143730 BC143733 AAI43734 BC143759 AAI43760 BG110813 BP202018 BT006935 AAP35581 CD642694 CN347006 CR749834 CAH18690 CX758421 CX872304 DA234399 DA855348 DA887235 DC340223 DR002874 EF090258 ABK78671 H77515 HQ258533 ADR83287 X76104 CAA53712 XM_005251757 XP_005251814 NM_001288729 NP_001275658 NM_001288730 NP_001275659 NM_001288731 NP_001275660 NM_004938 NP_004929
Function Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pa
Subcellular Location Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with MAP1B in the microtubules and cortical actin fibers.
Tissue Specificity Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas. {ECO:0000269|PubMed:18422656}.
Top Pathways Bladder cancer

DAPK1 Antibody - 3008 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using DAPK1 Antibody.

DAPK (17) - sc-136286 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
DAPK (17): sc-136286. Western blot analysis of DAPK expression in SKN whole cell lysate.

DAPK (C-20) - sc-8163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DAPK (C-20): sc-8163. Western blot analysis of human recombinant DAP-kinase fusion protein.

DAPK (H-300) - sc-10805 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DAPK (H-300): sc-10805. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic and membrane staining of glandular cells.

DAPK (N-19) - sc-8164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-DAPK (DKPS308) - sc-57540 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl ascites
Host Mouse
Clonality Monoclonal

Anti-DAP Kinase 1 (phospho S308) antibody [DKPS308] - ab10524 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone DKPS308

Anti-DAP Kinase 1 antibody - ab67286 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DAP Kinase 1 antibody - ab197783 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of COS7 cells, labeling DAP Kinase 1 using ab197783 at a 1/100 dilution. The sample on the right wasincubated with synthetic peptide.

Anti-DAP Kinase 1 antibody - ab193442 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DAP Kinase 1 antibody [DAPK-55] - ab10443 from Abcam

Prices $372.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone DAPK-55

Anti-DAP Kinase 1 antibody - C-terminal - ab189539 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DAP Kinase 1 antibody - C-terminal (ab189539) at 1/1000 dilution + Mouse brain total cell extract

Anti-DAPK1 / DAP Kinase Antibody - LS-C128527 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK1 / DAP Kinase Antibody (aa274-323) IHC-plus™ - LS-B11327 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DAPK1 / DAP Kinase antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11327 concentration 5 ug/ml.

Anti-DAPK1 / DAP Kinase Antibody (N-Terminus) IHC-plus™ - LS-B11632 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-DAPK1 / DAP Kinase Antibody (aa384-412, Biotin) - LS-C221996 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK1 / DAP Kinase Antibody (aa384-412, FITC) - LS-C221997 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK1 / DAP Kinase Antibody (aa384-412, PE) - LS-C221999 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK1 / DAP Kinase Antibody (aa384-412, Azide-free, HRP) - LS-C221998 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK1 / DAP Kinase Antibody (C-Terminus, AP) - LS-C225057 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK1 / DAP Kinase Antibody (clone 2E7) - LS-C197022 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E7
Detection limit for recombinant GST tagged DAPK1 is approximately 0.1 ng/ml as a capture antibody.

Anti-DAPK1 / DAP Kinase Antibody (aa385-412) - LS-C164359 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Dapk1 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The Dapk1 antibody detected the Dapk1 protein (arrow).

Anti-DAPK1 / DAP Kinase Antibody (C-Terminus, APC) - LS-C225058 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK1 / DAP Kinase Antibody (C-Terminus, Biotin) - LS-C225059 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPK1 / DAP Kinase Antibody (C-Terminus, FITC) - LS-C225060 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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