DAPK1

Gene Symbol	DAPK1
Entrez Gene	1612
Alt Symbol	DAPK
Species	Human
Gene Type	protein-coding
Description	death-associated protein kinase 1
Other Description	DAP kinase 1
Swissprots	Q1W5W0 Q6ZRZ3 P53355 B7ZLE7 Q9BTL8 Q68CP8 Q14CQ7 B7ZLD2
Accessions	ABD96827 EAW62725 EAW62726 EAW62727 EAW62728 P53355 AA846231 AA854055 AB208871 BAD92108 AK127855 BAC87163 AK295119 BAG58146 AK296839 BAH12440 BC113660 AAI13661 BC143730 BC143733 AAI43734 BC143759 AAI43760 BG110813 BP202018 BT006935 AAP35581 CD642694 CN347006 CR749834 CAH18690 CX758421 CX872304 DA234399 DA855348 DA887235 DC340223 DR002874 EF090258 ABK78671 H77515 HQ258533 ADR83287 X76104 CAA53712 XM_005251757 XP_005251814 NM_001288729 NP_001275658 NM_001288730 NP_001275659 NM_001288731 NP_001275660 NM_004938 NP_004929
Function	Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pa
Subcellular Location	Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with MAP1B in the microtubules and cortical actin fibers.
Tissue Specificity	Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas. {ECO:0000269|PubMed:18422656}.
Top Pathways	Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DAPK1 / DAP Kinase ELISA Kit (Sandwich ELISA) - LS-F7342 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse DAPK1 / DAP Kinase ELISA Kit (Sandwich ELISA) - LS-F8124 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.051 ng/ml Range 0.156-10 ng/ml

Human DAPK1 ELISA Kit - abx151254 from Abbexa Category ELISA Kit Sensitivity 0.052 ng/ml Range 0.156 ng/ml - 10 ng/ml

Death Associated Protein Kinase 1 (DAPK1), Human, ELISA Kit - SEC429Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.052ng/mL Range 0.156-10ng/mL

Death-associated protein kinase (DAPK), Human, ELISA Kit - CSB-E14181h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Death Associated Protein Kinase 1 (DAPK1), ELISA Kit - MBS2021178 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.062ng/mL. Range 0.156-10ng/mL

Death Associated Protein Kinase 1 (DAPK1), ELISA Kit - MBS2019499 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.051ng/mL. Range 0.156-10ng/mL

death-associated protein kinase 1, ELISA Kit - MBS702602 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7.81 pg/ml. Range 31.25 pg/ml -2000 pg/ml.

ELISA Kit for Death Associated Protein Kinase 1 (DAPK1) - SEC429Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Death Associated Protein Kinase 1 (DAPK1) - SEC429Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.051ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human death-associated protein kinase (DAPK) ELISA Kit - CSB-E14181h from Cusabio Category ELISA Kit Sensitivity 7.81pg/ml Range 31.25 pg/ml-2000 pg/ml

Death Associated Protein Kinase 1 (DAPK1), Human, ELISA Kit - DL-DAPK1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human DAPK1 ELISA Kit - abx571025 from Abbexa Category ELISA Kit Sensitivity 0.052 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human DAPK1 ELISA Kit - E011436 from Biobool Category ELISA Kit Sensitivity Typically less than 0.062ng/mL.

DAPK1 ELISA Kit (Human) (OKDD00222) - OKDD00222 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.052 ng/mL Range 0.156-10 ng/mL

Death Associated Protein Kinase 1 (DAPK1), ELISA Kit - MBS452781 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.052ng/mL Range 0.156-10ng/mL

Death Associated Protein Kinase 1 (DAPK1), ELISA Kit - MBS9372065 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human DAPK1 ELISA Kit - orb406202 from Biorbyt Category ELISA Kit Sensitivity 7.81pg/ml Range 31.25 pg/ml-2000 pg/ml

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