Gene Symbol | Prcp |
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Entrez Gene | 72461 |
Alt Symbol | 2510048K03Rik, 2610104A14Rik, AI451719, HUMPCP, PCP |
Species | Mouse |
Gene Type | protein-coding |
Description | prolylcarboxypeptidase (angiotensinase C) |
Other Description | lysosomal Pro-X carboxypeptidase|proline carboxypeptidase |
Swissprots | Q8R0T8 Q3V302 Q3TLW3 Q9D049 Q8BKK3 Q7TMR0 |
Accessions | EDL06718 Q7TMR0 AK011112 AK011816 BAB27858 AK030160 AK051677 BAC34716 AK054462 BAE20697 AK083719 AK166282 BAE38679 BC026424 AAH26424 BC055022 AAH55022 BC089575 XM_011241910 XP_011240212 NM_028243 NP_082519 |
Function | Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity). {ECO:0000250}. |
Subcellular Location | Lysosome {ECO:0000250}. |
Top Pathways | Protein digestion and absorption |
Angiotensinase C CRISPR/Cas9 KO Plasmid (m) - sc-428347 from Santa Cruz Biotechnology
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Angiotensinase C HDR Plasmid (m) - sc-428347-HDR from Santa Cruz Biotechnology
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Angiotensinase C Double Nickase Plasmid (m) - sc-428347-NIC from Santa Cruz Biotechnology
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Angiotensinase C Double Nickase Plasmid (m2) - sc-428347-NIC-2 from Santa Cruz Biotechnology
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Angiotensinase C CRISPR Activation Plasmid (m) - sc-428347-ACT from Santa Cruz Biotechnology
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Angiotensinase C CRISPR Activation Plasmid (m2) - sc-428347-ACT-2 from Santa Cruz Biotechnology
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Angiotensinase C Lentiviral Activation Particles (m) - sc-428347-LAC from Santa Cruz Biotechnology
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Angiotensinase C Lentiviral Activation Particles (m2) - sc-428347-LAC-2 from Santa Cruz Biotechnology
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Angiotensinase C siRNA (m) - sc-60171 from Santa Cruz Biotechnology
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Angiotensinase C shRNA Plasmid (m) - sc-60171-SH from Santa Cruz Biotechnology
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Angiotensinase C shRNA (m) Lentiviral Particles - sc-60171-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU036691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39249 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39249 from Sigma-Aldrich
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PRCP siRNA (Mouse) - CRM8798 from Cohesion Biosciences
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shRNA set against Mouse PRCP (NM_028243.3) - SHH382116 from Creative biogene
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PRCP shRNA Plasmid (Mouse) - CHM8798 from Cohesion Biosciences
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