PTPRC
| Gene Symbol | PTPRC |
|---|---|
| Entrez Gene | 5788 |
| Alt Symbol | B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, receptor type, C |
| Other Description | CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase, receptor type, c polypeptide|receptor-type tyrosine-protein phosphatase C |
| Swissprots | Q9H0Y6 P08575 Q16614 A8K7W6 |
| Accessions | AAA59497 AAD15273 AAG26082 AAM12758 AAS46922 AAS46930 AAS46938 AAS46946 AAS46954 AAS46962 CBU30438 CBU83087 EAW91300 EAW91301 EAW91302 EAW91303 P08575 AA403163 AA904360 AK130573 AK292131 BAF84820 AK299986 BAG61807 AK303539 BAG64565 AK307635 AK308217 AK310898 AY429565 AY429566 AY567999 AAS75254 BC014239 AAH14239 BC017863 AAH17863 BC031525 BC121086 AAI21087 BC121087 AAI21088 BC127656 AAI27657 BC127657 AAI27658 BC148257 AAI48258 BC169206 BC169207 BM791051 DA670254 DA819314 DA948670 Y00062 CAA68269 Y00638 CAA68669 XM_006711472 XP_006711535 XM_006711473 XP_006711536 XM_006711474 XP_006711537 NM_001267798 NP_001254727 NM_002838 NP_002829 NM_080921 NP_563578 NR_052021 NM_080922 |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:12676959}; Single-pass type I membrane protein {ECO:0000269|PubMed:12676959}. Membrane raft {ECO:0000269|PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts. |
| Top Pathways | T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Fc gamma R-mediated phagocytosis |
CD45 CRISPR/Cas9 KO Plasmid (h) - sc-400245 from Santa Cruz Biotechnology
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CD45 HDR Plasmid (h) - sc-400245-HDR from Santa Cruz Biotechnology
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CD45RC Double Nickase Plasmid (h) - sc-400245-NIC from Santa Cruz Biotechnology
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CD45 Double Nickase Plasmid (h2) - sc-400245-NIC-2 from Santa Cruz Biotechnology
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CD45RC CRISPR Activation Plasmid (h) - sc-400245-ACT from Santa Cruz Biotechnology
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CD45 CRISPR Activation Plasmid (h2) - sc-400245-ACT-2 from Santa Cruz Biotechnology
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CD45RC Lentiviral Activation Particles (h) - sc-400245-LAC from Santa Cruz Biotechnology
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CD45 Lentiviral Activation Particles (h2) - sc-400245-LAC-2 from Santa Cruz Biotechnology
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CD45 siRNA (h) - sc-29251 from Santa Cruz Biotechnology
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CD45 shRNA Plasmid (h) - sc-29251-SH from Santa Cruz Biotechnology
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CD45 shRNA (h) Lentiviral Particles - sc-29251-V from Santa Cruz Biotechnology
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CD45 RNAi - H00005788-R03 from Novus Biologicals
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CD45 RNAi - H00005788-R02 from Novus Biologicals
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CD45 RNAi - H00005788-R01 from Novus Biologicals
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MISSION® esiRNA - EHU060871 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1097 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0784 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0786 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1095 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1096 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0785 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1098 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17707 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17707 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08882 from Sigma-Aldrich
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