EPOR

Gene Symbol	EPOR
Entrez Gene	2057
Alt Symbol	EPO-R
Species	Human
Gene Type	protein-coding
Description	erythropoietin receptor
Other Description	-
Swissprots	Q2M205 B2RCG4 P19235 Q15443
Accessions	AAA52392 AAA52393 AAB23271 AAB34703 ABX71216 AFM52330 AFM52331 EAW84205 EAW84206 EAW84207 EAW84208 P19235 AK315097 BAG37561 BC019092 BC112153 AAI12154 BC143697 BC143698 BC143700 BU619338 M34986 AAA52401 M60459 AAA52403 X57282 CAA40550 X97671 CAA66260 NM_000121 NP_000112 NR_033663
Function	Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Erythropoietin R (NP_000112) VersaClone cDNA - RDC1158 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

Human EPOR ORF Clone(NM_000121.3) - CDCL162508 from Creative Biomart Species Human Accession NM_000121.3

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone in cloning vector - HG13305-G from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13305-NF from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13305-NM from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13305-CF from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG13305-NH from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13305-CM from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13305-NY from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13305-ACR from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG13305-CH from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13305-ACG from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid - HG13305-UT from Sino Biological Species Human

Human EPOR/Erythropoietin Receptor transcript variant 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13305-CY from Sino Biological Species Human

Human EPOR ORF clone (NR_033663.1) - CDCB159996 from Creative biogene Species Human

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