Gene Symbol |
Gabarapl2
|
Entrez Gene |
64670
|
Alt Symbol |
Gef2
|
Species |
Rat
|
Gene Type |
protein-coding
|
Description |
GABA(A) receptor-associated protein like 2
|
Other Description |
GABA(A) receptor-associated protein-like 2|GATE-16|GEF-2|gamma-aminobutyric acid receptor-associated protein-like 2|ganglioside expression factor 2|golgi-associated ATPase enhancer of 16 kDa
|
Swissprots |
P60522
|
Accessions |
EDL92595 P60522 AB003515 BAA19975 BC058145 AAH58145 BC088139 AAH88139 FQ216852 FQ217289 FQ226397 FQ231643 FQ233551 FQ234861 NM_022706 NP_073197
|
Function |
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.
|
Subcellular Location |
Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome.
|
Top Pathways |
GABAergic synapse, Regulation of autophagy
|