| Gene Symbol | Gabarapl2 |
|---|---|
| Entrez Gene | 64670 |
| Alt Symbol | Gef2 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | GABA(A) receptor-associated protein like 2 |
| Other Description | GABA(A) receptor-associated protein-like 2|GATE-16|GEF-2|gamma-aminobutyric acid receptor-associated protein-like 2|ganglioside expression factor 2|golgi-associated ATPase enhancer of 16 kDa |
| Swissprots | P60522 |
| Accessions | EDL92595 P60522 AB003515 BAA19975 BC058145 AAH58145 BC088139 AAH88139 FQ216852 FQ217289 FQ226397 FQ231643 FQ233551 FQ234861 NM_022706 NP_073197 |
| Function | Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome. |
| Top Pathways | GABAergic synapse, Regulation of autophagy |
CompoZr® Knockout ZFN Kit - CKOZFN54238 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND54238 from Sigma-Aldrich
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GABARAPL2 siRNA (Rat) - CRR1986 from Cohesion Biosciences
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GABARAPL2 - MBS829908 from MyBioSource
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shRNA set against Rat GABARAPL2 (NM_022706.2) - SHH298377 from Creative biogene
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shRNA set against Rat Gabarapl2(NM_022706.2) - SHH073271 from Creative biogene
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GABARAPL2 shRNA Plasmid (Rat) - CHR1986 from Cohesion Biosciences
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GABARAPL2 miRNA 3'UTR clone - MiUTR1R-02005 from Creative biogene
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