| Gene Symbol | Tnfrsf13b |
|---|---|
| Entrez Gene | 57916 |
| Alt Symbol | 1200009E08Rik, Taci |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | tumor necrosis factor receptor superfamily, member 13b |
| Other Description | transmembrane activator and CAML interactor|transmembrane activator and calcium-modulating and cyclophilin ligand interactor|tumor necrosis factor receptor superfamily member 13B |
| Swissprots | Q9DBZ3 Q9ET35 |
| Accessions | CAF03581 CAJ90565 CAJ90570 CBY65606 Q9ET35 AF257673 AAG00081 AK004668 BAB23457 AK155178 BAE33096 BC139392 AAI39393 BC139393 AAI39394 BC141867 AAI41868 BC141868 AAI41869 XM_006533851 XP_006533914 XM_006533852 XP_006533915 NM_021349 NP_067324 |
| Function | Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Primary immunodeficiency, Intestinal immune network for IgA production |