| Gene Symbol |
Nat8l
|
| Entrez Gene |
269642
|
| Alt Symbol |
1110038O08Rik, Shati
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
N-acetyltransferase 8-like
|
| Other Description |
N-acetylaspartate synthetase|N-acetyltransferase 8-like protein|NAA synthetase|protein Shati
|
| Swissprots |
Q6DID6 Q8K065 Q3UH43 Q3UGX3
|
| Accessions |
EDL37443 Q3UGX3 AK004167 AK147307 BAE27836 AK147594 BAE28014 AK147703 BAE28084 BC034068 AAH34068 BC075616 AAH75616 DQ174094 ABA54615 NM_001001985 NP_001001985
|
| Function |
Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. {ECO:0000269|PubMed:19014384, ECO:0000269|PubMed:19807691, ECO:0000269|PubMed:20385109, ECO:0000269|PubMed:20643647}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Expressed in brain, kidney, liver and spleen. In brain, present in neurons but not in astrocytes (at protein level). Expressed in brain, thymus and spleen. {ECO:0000269|PubMed:17626222, ECO:0000269|PubMed:19807691, ECO:0000269|PubMed:20385109}.
|
| Top Pathways |
Alanine, aspartate and glutamate metabolism
|