LEP

Gene Symbol LEP
Entrez Gene 3952
Alt Symbol LEPD, OB, OBS
Species Human
Gene Type protein-coding
Description leptin
Other Description leptin (murine obesity homolog)|leptin (obesity homolog, mouse)|obese protein|obese, mouse, homolog of|obesity factor
Swissprots O15158 P41159 Q56A88
Accessions AAC31660 AAX81413 AAY46797 BAA09787 BAA09839 CBI71013 EAL24315 EAW83640 P41159 AF008123 AAB63507 AK313553 BAG36329 BC060830 AAH60830 BC069323 AAH69323 BC069452 AAH69452 BC069527 AAH69527 BU752306 D49487 BAA08448 DA762132 HQ448411 ADQ32891 U18915 AAA60470 U43653 AAC50400 XM_005250340 XP_005250397 NM_000230 NP_000221
Function May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Subcellular Location Secreted.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

Ob (H-5) - sc-393043 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ob (H-5): sc-393043. Western blot analysis of human recombinant Ob.

Ob (A-20) - sc-842 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ob (A-20): sc-842. Immunofluorescence staining of methanol-fixed JAR cells showing cytoplasmic localization.

Ob (B-4) - sc-28344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ob (B-4): sc-28344. Western blot analysis of human recombinant Ob.

Ob (F-3) - sc-48408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ob (F-3): sc-48408. Western blot analysis of human recombinant Ob.

Ob (H-146) - sc-9014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ob (H-146): sc-9014. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast cancer tissue showing cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Ob (Y-20) - sc-843 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ob (Y-20): sc-843. Western blot analysis of human recombinant Ob protein (leptin).

Anti-Leptin antibody - ab117751 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab117751 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab117751 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Leptin antibody - ab7208 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Standard curve for Leptin (Analyte: ab51273); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [BDI170] to Leptin (ab20101) at 1/200 and Detector Antibody Rabbit polyclonal to Leptin (ab7208) at 0.5µg/ml. Concentration of Mouse monoclonal [BDI170] to Leptin (ab20101) may vary from lot to lot; please use this curve as guideline.

Anti-Leptin antibody - ab28953 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
Anti-Leptin antibody (ab28953) at 1/1000 dilution + Human leptin

Anti-Leptin antibody - ab9826 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Leptin antibody - ab31216 from Abcam

Host Chicken
Clonality Polyclonal
Anti-Leptin antibody (ab31216) at 1/2000 dilutionSecondaryGoat anti IgY-HRP developed using the ECL technique

Anti-Leptin antibody - ab13986 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Leptin antibody - ab9828 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-Leptin antibody [10H1] (HRP) - ab6055 from Abcam

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 10H1

Anti-Leptin antibody [3G7] - ab6056 from Abcam

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 3G7

Anti-Leptin antibody [4F12] - ab6057 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F12

Anti-Leptin antibody [4F8] - ab1976 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 4F8

Anti-Leptin antibody [5F10] - ab6058 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5F10

Anti-Leptin antibody [9C10] - ab36498 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 9C10

Anti-Leptin antibody [BDI142] - ab20115 from Abcam

Prices $372.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone BDI142

Anti-Leptin antibody [BDI170] - ab20101 from Abcam

Host Mouse
Clonality Monoclonal
Clone BDI170
Standard curve for Leptin (Analyte: ab51273); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [BDI170] to Leptin (ab20101) at 1/200 dilution and Detector Antibody Rabbit polyclonal to Leptin (ab7208) at 0.5µg/ml. Concentration of Mouse monoclonal [BDI170] to Leptin (ab20101) may vary from lot to lot; please use this curve as guideline.

Anti-Leptin Antibody (aa149-167) - LS-C3334 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Leptin Antibody - LS-C19018 from LifeSpan Bioscience

Prices $395.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-Leptin Antibody (clone YD-HLEP4B6) - LS-C25161 from LifeSpan Bioscience

Prices $375.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone YD-HLEP4B6

Anti-Leptin Antibody (aa25-44) - LS-C25175 from LifeSpan Bioscience

Prices $515.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
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