LEP

Gene Symbol LEP
Entrez Gene 3952
Alt Symbol LEPD, OB, OBS
Species Human
Gene Type protein-coding
Description leptin
Other Description leptin (murine obesity homolog)|leptin (obesity homolog, mouse)|obese protein|obese, mouse, homolog of|obesity factor
Swissprots O15158 P41159 Q56A88
Accessions AAC31660 AAX81413 AAY46797 BAA09787 BAA09839 CBI71013 EAL24315 EAW83640 P41159 AF008123 AAB63507 AK313553 BAG36329 BC060830 AAH60830 BC069323 AAH69323 BC069452 AAH69452 BC069527 AAH69527 BU752306 D49487 BAA08448 DA762132 HQ448411 ADQ32891 U18915 AAA60470 U43653 AAC50400 XM_005250340 XP_005250397 NM_000230 NP_000221
Function May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Subcellular Location Secreted.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

Ob CRISPR/Cas9 KO Plasmid (h) - sc-400706 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob HDR Plasmid (h) - sc-400706-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob Double Nickase Plasmid (h) - sc-400706-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob Double Nickase Plasmid (h2) - sc-400706-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob CRISPR Activation Plasmid (h) - sc-400706-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob CRISPR Activation Plasmid (h2) - sc-400706-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob Lentiviral Activation Particles (h) - sc-400706-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob Lentiviral Activation Particles (h2) - sc-400706-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob siRNA (h) - sc-37189 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ob shRNA Plasmid (h) - sc-37189-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ob shRNA (h) Lentiviral Particles - sc-37189-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU012751 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1658 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1658 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LEP siRNA (Human) - CRH2675 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Leptin/OB RNAi - H00003952-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Ob CRISPR/Cas9 KO Plasmid (h2) - sc-400706-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ob HDR Plasmid (h2) - sc-400706-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human LEP (NM_000230.2) - SHH329607 from Creative biogene

Category siRNA
Species Reactivities Human

Human LEP siRNA - orb263177 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LEP shRNA Plasmid (Human) - CHH2675 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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